Mouse (Dose) | Drug-Related Exposure (%) | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
AZD4831 | M1 | M2 | M3 | M4 | M5 | M7 | M9 | M10 | M11 | M12 | M14 | |
Female (125 mg/kg) | 76 | 4.6 | 4.8 | ND | ND | 11 | ND | ND | 2.6 | ND | 0.8 | 1.0 |
Female (250 mg/kg) | 74 | 6.2 | 5.8 | 0.01 | ND | 7.6 | 1.6 | ND | 2.4 | ND | 0.6 | 1.5 |
Female (500 mg/kg) | 57 | 19 | 7.6 | 0.08 | 0.2 | 4.7 | 6.1 | 0.01 | 1.8 | 0.004 | 0.4 | 3.1 |
Male (125 mg/kg) | 78 | 1.8 | 2.6 | ND | ND | 14 | ND | ND | 2.8 | ND | 0.8 | 0.2 |
Male (250 kg/mg) | 71 | 6.8 | 4.5 | 0.04 | 0.2 | 11 | 1.7 | ND | 2.6 | ND | 0.7 | 1.3 |
Male (500 mg/kg) | 60 | 16 | 5.6 | 0.10 | 0.2 | 5.5 | 7.5 | 0.02 | 1.9 | 0.004 | 0.4 | 2.6 |
ND, not detected.