Parameter | Symbol | Atomoxetine | 4-Hydroxyatomoxetine | N-Desmethylatomoxetine |
---|---|---|---|---|

Molecular weight | MW | 255 | 271 | 241 |

Octanol-water partition coefficient | logP | 3.94 | 3.45 | 3.67 |

Acid dissociation constant | pK_{a} | 9.6 (base) | 9.4 (base) 10.4 (acid) | 9.2 (base) |

Plasma unbound fraction | f_{u,p} | 0.157 | 0.750 | 0.194 |

Blood-plasma concentration ratio | R_{b} | 0.872 | 0.827 | 0.889 |

Liver-plasma concentration ratio | K_{p,h} | 7.27 | 9.83 | 7.15 |

The liver (kidney)-to-plasma concentration ratios (

*K*_{p,h}/*K*_{p,r}) and the blood-to-plasma concentration ratio (*R*_{b}) were calculated from the*f*_{u,p,}and log*P*values as follows (Adachi et al., 2023c):