TABLE 1

Pharmacokinetic parameters of atomoxetine and its metabolites after an intravenous dose of 3.0 mg/kg body weight in both untreated humanized liver mice and those pretreated for 3 days with paroxetine (8.0 mg/kg)

The numbers in parentheses are the fold values compared with the untreated group.

GroupAtomoxetineTotal 4-HydroxyatomoxetineN-DesmethylatomoxetineSum of AUC, nmol·h/ml
C0, μg/mlAUC, nmol·h/mlCmax, μg/mlAUC, nmol·h/mlCmax, μg/mlAUC, nmol·h/ml
Untreated, n = 60.47 ± 0.09 (1.0)2.0 ± 0.4 (1.0)2.5 ± 0.4 (1.0)23 ± 2 (1.0)0.003 ± 0.001 (1.0)0.038 ± 0.006 (1.0)25 ± 2 (1.0)
Treated, n = 60.61 ± 0.15 (1.3)8.7 ± 1.8 (4.4*)0.59 ± 0.32 (0.24*)12 ± 6 (0.52*)0.032 ± 0.017 (11*)0.61 ± 0.32 (16*)21 ± 5 (0.84)
  • *Significantly different compared with untreated mice, P < 0.05.