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Drug Metabolism & Disposition

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drug-drug interactions

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    An improved method for cytochrome p450 reaction phenotyping using a sequential qualitative-then-quantitative approach.
    Angela C. Doran, Alyssa L Dantonio, Gabrielle M Gualtieri, Amanda Balesano, Connor Landers, Woodrow Burchett, Theunis C. Goosen and R. Scott Obach
    Drug Metabolism and Disposition July 1, 2022, DMD-AR-2022-000883; DOI: https://doi.org/10.1124/dmd.122.000883
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    In vitro CYP450 enzyme down-regulation by GLP-1/glucagon co-agonist does not translate to observed drug-drug interactions in the clinic
    Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Haljeta Friedrichsen, Sune Boris Nygård and Kim Kristensen
    Drug Metabolism and Disposition June 9, 2022, DMD-AR-2022-000865; DOI: https://doi.org/10.1124/dmd.122.000865
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    Isotretinoin and its metabolites alter mRNA of multiple enzyme and transporter genes in vitro but downregulation of OATP1B1 does not translate to the clinic
    Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen
    Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000882; DOI: https://doi.org/10.1124/dmd.122.000882
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    Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
    Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W Yucha, Swapan K. Chowdhury and Paresh P. Chothe
    Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000836; DOI: https://doi.org/10.1124/dmd.122.000836
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    Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models
    Yuli Qian and John S. Markowitz
    Drug Metabolism and Disposition May 5, 2022, DMD-AR-2021-000823; DOI: https://doi.org/10.1124/dmd.121.000823
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