drug-drug interactions

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An improved method for cytochrome p450 reaction phenotyping using a sequential qualitative-then-quantitative approach.
Angela C. Doran, Alyssa L Dantonio, Gabrielle M Gualtieri, Amanda Balesano, Connor Landers, Woodrow Burchett, Theunis C. Goosen and R. Scott Obach

Drug Metabolism and Disposition July 1, 2022, DMD-AR-2022-000883; DOI: https://doi.org/10.1124/dmd.122.000883
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In vitro CYP450 enzyme down-regulation by GLP-1/glucagon co-agonist does not translate to observed drug-drug interactions in the clinic
Carolina Säll, Lene Alifrangis, Kirsten Dahl, Martin Haljeta Friedrichsen, Sune Boris Nygård and Kim Kristensen

Drug Metabolism and Disposition June 9, 2022, DMD-AR-2022-000865; DOI: https://doi.org/10.1124/dmd.122.000865
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Isotretinoin and its metabolites alter mRNA of multiple enzyme and transporter genes in vitro but downregulation of OATP1B1 does not translate to the clinic
Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000882; DOI: https://doi.org/10.1124/dmd.122.000882
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Sinusoidal Uptake Determines the Hepatic Clearance of Pevonedistat (TAK-924) as Explained by Extended Clearance Model
Philip Sandoval, Bei-Ching Chuang, Lawrence Cohen, Tomoki Yoneyama, Sandeepraj Pusalkar, Robert W Yucha, Swapan K. Chowdhury and Paresh P. Chothe

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000836; DOI: https://doi.org/10.1124/dmd.122.000836
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Prediction of Carboxylesterase 1 (CES1)-mediated In Vivo Drug Interaction between Methylphenidate and Cannabinoids using Static and Physiologically Based Pharmacokinetic Models
Yuli Qian and John S. Markowitz

Drug Metabolism and Disposition May 5, 2022, DMD-AR-2021-000823; DOI: https://doi.org/10.1124/dmd.121.000823

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