hepatocytes

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Extension of the mechanistic tissue distribution model of Rodgers & Rowland by systematic incorporation of lysosomal trapping: impact on Kpu and volume of distribution predictions in the rat
Maximilian V. Schmitt, Andreas Reichel, Xiaohui Liu, Gert Fricker and Philip Lienau

Drug Metabolism and Disposition November 4, 2020, DMD-AR-2020-000161; DOI: https://doi.org/10.1124/dmd.120.000161
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Considerations from the Innovation and Quality Induction Working Group in Response to Drug-Drug Interaction Guidance from Regulatory Agencies: Guidelines on Model Fitting and Recommendations on Time Course for In Vitro CYP Induction Studies Including Impact on Drug Interaction Risk Assessment
Simon G Wong, Diane Ramsden, Shannon Dallas, Conrad Fung, Heidi J. Einolf, Jairam Palamanda, Liangfu Chen, Theunis C. Goosen, Yin Fai Amy Siu, George Zhang, Donald J. Tweedie, Niresh Hariparsad, Barry C. Jones and Phillip D Yates

Drug Metabolism and Disposition November 2, 2020, DMD-PER-2020-000055; DOI: https://doi.org/10.1124/dmd.120.000055
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Down-regulation of CYP1A2, CYP2B6, and CYP3A4 in human hepatocytes by prolyl hydroxylase domain 2 inhibitors via hypoxia-inducible factor-α stabilization
Hiroki Takano, Jun-ichi Yamaguchi, Sota Kato, Makoto Hamada, Mika Tada and Hiromi Endo

Drug Metabolism and Disposition October 21, 2020, DMD-AR-2020-000124; DOI: https://doi.org/10.1124/dmd.120.000124

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