nuclear receptors

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Characterization of JNJ-2482272 [4-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-yl)pyrimidine-2-amine] as a Strong AhR Activator in Rat and Human
Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P Scott, Judith Skaptason, Yuen Tam, Laurie P Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M Lim, Michael Hack and Tatiana Koudriakova

Drug Metabolism and Disposition June 9, 2022, DMD-AR-2021-000825; DOI: https://doi.org/10.1124/dmd.121.000825
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Repression of OATP1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Down-regulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen

Drug Metabolism and Disposition May 30, 2022, DMD-AR-2022-000875; DOI: https://doi.org/10.1124/dmd.122.000875
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Isotretinoin and its metabolites alter mRNA of multiple enzyme and transporter genes in vitro but downregulation of OATP1B1 does not translate to the clinic
Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen

Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000882; DOI: https://doi.org/10.1124/dmd.122.000882
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Distinct roles of the sister nuclear receptors PXR and CAR in liver cancer development
Kouichi Yoshinari and Ryota Shizu

Drug Metabolism and Disposition February 19, 2022, DMD-MR-2021-000481; DOI: https://doi.org/10.1124/dmd.121.000481
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Searching for CAR modulators
Paavo Honkakoski

Drug Metabolism and Disposition February 19, 2022, DMD-MR-2021-000482; DOI: https://doi.org/10.1124/dmd.121.000482
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Regulation of transporters by perfluorinated carboxylic acids in HepaRG cells
Joe Jongpyo Lim, Youjun Suh, Elaine M Faustman and Julia Yue Cui

Drug Metabolism and Disposition December 14, 2021, DMD-AR-2021-000477; DOI: https://doi.org/10.1124/dmd.121.000477

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