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Drug Metabolism & Disposition

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nuclear receptors

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    Characterization of JNJ-2482272 [4-(4-methyl-2-(4-(trifluoromethyl)phenyl)thiazole-5-yl)pyrimidine-2-amine] as a Strong AhR Activator in Rat and Human
    Kevin J. Coe, Mark Feinstein, J. William Higgins, Perry Leung, Brian P Scott, Judith Skaptason, Yuen Tam, Laurie P Volak, Jennifer Kinong, Anton Bittner, Heather McAllister, Nathan M Lim, Michael Hack and Tatiana Koudriakova
    Drug Metabolism and Disposition June 9, 2022, DMD-AR-2021-000825; DOI: https://doi.org/10.1124/dmd.121.000825
  • You have access
    Repression of OATP1B Expression and Increase of Plasma Coproporphyrin Level as Evidence for OATP1B Down-regulation in Cynomolgus Monkeys Treated with Chenodeoxycholic Acid
    Yueping Zhang, Shen-Jue Chen, Cliff Chen, Xue-Qing Chen, Sagnik Chatterjee, David J. Shuster, Heather Dexter, Laura Armstrong, Elizabeth M. Joshi, Zheng Yang and Hong Shen
    Drug Metabolism and Disposition May 30, 2022, DMD-AR-2022-000875; DOI: https://doi.org/10.1124/dmd.122.000875
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    Isotretinoin and its metabolites alter mRNA of multiple enzyme and transporter genes in vitro but downregulation of OATP1B1 does not translate to the clinic
    Aprajita S. Yadav, Faith Stevison, Mika Kosaka, Susan Wong, Jane R. Kenny, John K. Amory and Nina Isoherranen
    Drug Metabolism and Disposition May 11, 2022, DMD-AR-2022-000882; DOI: https://doi.org/10.1124/dmd.122.000882
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    Distinct roles of the sister nuclear receptors PXR and CAR in liver cancer development
    Kouichi Yoshinari and Ryota Shizu
    Drug Metabolism and Disposition February 19, 2022, DMD-MR-2021-000481; DOI: https://doi.org/10.1124/dmd.121.000481
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    Searching for CAR modulators
    Paavo Honkakoski
    Drug Metabolism and Disposition February 19, 2022, DMD-MR-2021-000482; DOI: https://doi.org/10.1124/dmd.121.000482
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    Regulation of transporters by perfluorinated carboxylic acids in HepaRG cells
    Joe Jongpyo Lim, Youjun Suh, Elaine M Faustman and Julia Yue Cui
    Drug Metabolism and Disposition December 14, 2021, DMD-AR-2021-000477; DOI: https://doi.org/10.1124/dmd.121.000477
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