l-Bunolol Metabolism in Rats: Identification of Urinary Metabolites

https://doi.org/10.1002/jps.2600670138Get rights and content

Abstract

Urine collected for 24 hr from rats given a single oral dose of 3HH-l-bunolo(l1 0 mg/kg) was found to contain only 25.8% of the dose and more than 30 labeled compounds. Nine compounds were identified and quantified as follows: bunolol (0.35% of urinary tritium), bunolol glucuronide (5.12%). bunolol sulfate (0.08%), dihydrobunolol (0.08%), dihydrobunolol glucuronide (0.74%), dihydrobunolol sulfate (0.12%), hydroxydihydrobunolol (0.58%).β-(5-oxytetralonyl)lactica cid (0.74%), and (5-oxytetralonyl)acetic acid glucuronide (1.12%). The total quantity of identified labeled compounds was only 2.3% of the dose and 8.9% of the urinary radioactivity.

REFERENCES (7)

  • F.-J. Leinweber et al.

    J. harrn. Sci

    (1971)
  • F.-J. Leinweber et al.

    J. harrn. Sci.

    (1971)
  • F.-J. Leinweber et al.

    J. harrn. Sci

    (1977)
There are more references available in the full text version of this article.

Cited by (6)

*

Present address: Department of Biochemistry and Drug Metabolism, Hoffmann-La Roche Inc., Nutley, NJ 07110

Present address: Office of Toxic Substances (WH-557), US. Environmental Protection Agency, Washington, DC 20460

View full text