Research ArticlesBinding of Fluvastatin to Blood Cells and Plasma Proteins
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2021, Analytica Chimica ActaCitation Excerpt :However, although no chiral resolution was achieved for the basic racemates (±)-atenolol, (±)-metoprolol and (±)-propranolol, the (±)-verapamil racemate was instead enantioselectively retained to some extent. Interestingly, even if a fluvastatin/salicylic acid competitive binding to the HSA has been reported by Tse et al. [47], no variation in the retention factors was recorded when these compounds were individually measured. Furthermore, Jattinagoudar and co-workers claimed that according to spectroscopy and molecular docking-based studies they carried out [48], the secondary structure of serum albumin was changed in the presence of fexofenadine.
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