Regular ArticleRing Hydroxylation of [o-3H]Methoxychlor as a Probe for Liver Microsomal CYP2B Activity: Potential forin VivoCYP2B Assay
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Oxidative demethylenation and subsequent glucuronidation are the major metabolic pathways of berberine in rats
2009, Journal of Pharmaceutical SciencesCitation Excerpt :The effects of several human selective P450 inhibitors on the formation of the Phase I metabolites M1 and M2 in rat liver microsomes were investigated. The inhibitors used were: α-naphthoflavone (for CYP1A),17 quinidine (for CYP2D1),18 orphenadrine (for CYP2B),19,20 diethyldithiocarbamate (for CYP2E1),21 sulfaphenazole (for CYP2C6/11),22 and ketoconazole (for CYP3A1/2).23 The concentrations used for BBR were 10, 50, and 200 µM and the concentrations of various inhibitors used were 2 and 10 µM for quinidine, 1 and 10 µM for α-naphthoflavone, 10 and 50 µM for sulfaphenazole, 25 and 50 µM for orphenadrine, 12.5 and 25 µM for diethyldithiocarbamate, 1 and 10 µM for ketoconazole.
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1998, Biochemical PharmacologyProluciferin acetals as bioluminogenic substrates for cytochrome P450 activity and probes for CYP3A inhibition
2011, Drug Metabolism and DispositionFunctional expression and comparative characterization of nine murine cytochromes P450 by fluorescent inhibition screening
2008, Drug Metabolism and DispositionThe functional role of CYP2B6 in human drug metabolism: Substrates and inhibitors in vitro, in vivo and in silico
2006, Current Drug Metabolism
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