Regular ArticleMolecular Cloning and Characterization of a Novel Putative Carboxylesterase, Present in Human Intestine and Liver☆
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2017, FitoterapiaCitation Excerpt :In human, two primary CEs including hCE1 and hCE2 have been found and extensively studied in the past decade. hCE1 and hCE2 share 47% amino acid sequence identity, but exhibit differential tissue distribution and distinct substrate and inhibitor specificities [6–8]. Both hCE1 and hCE2 are mainly localized within the endoplasmic reticulum (ER) membranes in different mammalian tissues (such as liver and intestine).
Fructus Psoraleae contains natural compounds with potent inhibitory effects towards human carboxylesterase 2
2015, FitoterapiaCitation Excerpt :Generally, hCE1 preferentially hydrolyzes substrate with a small alcohol group and large acyl group [4]. In sharp contrast, hCE2 preferentially catalyzes substrates with a large alcohol group and small acyl group [3,10,11]. As the major carboxylesterase distributed in human intestine and tumor tissues, hCE2 is considered to play the most important role on the bioavailability of oral prodrugs, and the treatment outcomes of ester anti-cancer agents [7,8].
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W. B. Jakoby, Ed.
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