Biochemical and Biophysical Research Communications
Volume 275, Issue 3, 7 September 2000, Pages 795-803
Regular ArticleStructure–Activity Studies of Verapamil Analogs That Modulate Transport of Leukotriene C4 and Reduced Glutathione by Multidrug Resistance Protein MRP1☆,☆☆
References (42)
- et al.
Structural, mechanistic and clinical aspects of MRP1
Biochim. Biophys. Acta
(1999) - et al.
Membrane topology of the multidrug resistance protein, MRP: A study of glycosylation-site mutants reveals an extracytosolic NH2-terminus
J. Biol. Chem.
(1997) - et al.
Multidrug resistance protein (MRP)-mediated transport of leukotriene C4 and chemotherapeutic agents in membrane vesicles: Demonstration of glutathione-dependent vincristine transport
J. Biol. Chem.
(1996) - et al.
Chemosensitisation and drug accumulation effects of cyclosporin A, PSC-833 and verapamil in human MDR large cell lung cancer cells expressing a 190k membrane protein distinct from P-glycoprotein
Eur. J. Cancer
(1993) - et al.
Mechanisms of multidrug resistance in HL60 cells: Analysis of resistance associated membrane proteins and levels of mdr gene expression
Biochem. Pharmacol.
(1989) - et al.
ATPase activity of purified and reconstituted multidrug resistance protein MRP1 from drug-selected H69AR cells
Biochim. Biophys. Acta
(1999) - et al.
The effect of glutathione on the ATPase activity of MRP1 in its natural membranes
FEBS Lett.
(2000) - et al.
Multidrug resistance mediated by the Multidrug Resistance Protein (MRP) gene
Biochem. Pharmacol.
(1996) - et al.
The relationship between modulation of MDR and glutathione in MRP-overexpressing human leukemia cells
Biochem. Pharmacol.
(1998) - et al.
Glutathione depletion in human and in rat multi-drug resistant breast cancer cell lines
Biochem. Pharmacol.
(1991)
Reversal of multidrug resistance by verapamil analogues
Biochem. Pharmacol.
(1995)
Novel dithiane analogues of tiapamil with high activity to overcome multidrug resistance in vitro
Biochem. Pharmacol.
(1995)
The dithiane Ro 44-5912 enhances vinblastine sensitivity of drug resistant and parental KB lines in vivo
Eur. J. Cancer
(1995)
Increased levels of the multidrug resistance protein in lateral membranes of proliferating hepatocyte-derived cells
Gastroenterology
(1997)
Immunohistochemical detection of P-glycoprotein: Prognostic correlation in soft tissue sarcoma of childhood
J. Clin. Oncol.
(1990)
Multidrug resistance protein (MRP) expression in retinoblastoma correlates with rare failure of chemotherapy despite cyclosporine for reversal of P-glycoprotein
Cancer Res.
(1997)
Overexpression of a transporter gene in a multidrug-resistant human lung cancer cell line
Science
(1992)
Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2
Cancer Res.
(1999)
Pharmacological characterization of multidrug resistant MRP-transfected human tumor cells
Cancer Res.
(1994)
The P-glycoprotein efflux pump: How does it transport drugs?
J. Memb. Biol.
(1997)
Cited by (0)
- ☆
Abbreviations used: MRP1, multidrug resistance protein; LTC4, leukotriene C4; DTT, dithiothreitol; GSH, reduced glutathione; PBS, phosphate-buffered saline; HPLC, high performance liquid chromatography.
- ☆☆
This work was supported by Grant MT-10519 from the Medical Research Council of Canada (MRCC).
- 2
C.J.O. is the recipient of a MRCC Doctoral Award.
- 3
R.G.D. is the Stauffer Research Professor of Queen's University.
- 4
S.P.C.C. is a Senior Scientist of Cancer Care Ontario.
Copyright © 2000 Academic Press. All rights reserved.