REGULAR ARTICLESuppression of Collagen-Induced Arthritis by an Angiogenesis Inhibitor, AGM-1470, in Combination with Cyclosporin: Reduction of Vascular Endothelial Growth Factor (VEGF)
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The immunopharmacologic potential of Semaxanib and new generation directed therapeutic drugs: Receptor tyrosine kinase regulation with anti-tumorigenensis/angiogenesis properties
2012, Saudi Pharmaceutical JournalCitation Excerpt :This family includes several members including VEGF, placenta growth factor (PlGF), VEGF-B, VEGF-C, VEGF-D and two VEGF-like proteins encoded by parapoxvirus orf virus. In particular, VEGF, referred to also as VEGF-A, is a major regulator of normal and abnormal angiogenesis, including those associated with tumors (Oliver et al., 1995). Angiogenesis is a mechanistic developmental process, which involves the generation and growth of new blood vessels (neo-vascularization) from pre-existing vasculature (Vlodavsky et al., 1990; Klagbrun and D’Amore, 1991; Pili et al., 2001).
Neoangiogenesis contributes to the development of hemophilic synovitis
2011, BloodCitation Excerpt :Unfortunately, because of limitations of synovium sample procurement, we could not demonstrate mRNA expression of these angiogenic mediators in the synovium, which may have further strengthened evidence for a VEGF-induced cascade leading to synovitis. Measurement of serum VEGF levels has proven useful in evaluating the disease severity, more rapid disease progression,35 and response to treatment in both rat collagen-induced arthritis and patients with ovarian cancer.36,37 In HJD subjects, elevated VEGF-A levels as well as levels of circulating hematopoietic and endothelial progenitor cells may signify the onset and progression of synovitis.
Scopolin isolated from Erycibe obtusifolia Benth stems suppresses adjuvant-induced rat arthritis by inhibiting inflammation and angiogenesis
2009, International ImmunopharmacologyRegulation of VEGF mRNA expression and protein secretion by TGF-β2 in human retinal pigment epithelial cells
2007, Experimental Eye ResearchCitation Excerpt :In contrast, inhibition of VEGF expression by cyclosporine A has been less well characterized, but supported by our data. In addition to its immunomodulating effect, cyclosporine A has been demonstrated to have anti-angiogenic ability (Oliver et al., 1995; Hernandez et al., 2001). Specifically, cyclosporine A was found to inhibit human fibroblast VEGF expression induced by TGF-β (Cho et al., 2002).
Efficacy of anti-angiogenic treatment of tumors in old versus young mice
2006, Mechanisms of Ageing and DevelopmentTuftsin binds neuropilin-1 through a sequence similar to that encoded by exon 8 of vascular endothelial growth factor
2006, Journal of Biological ChemistryCitation Excerpt :Although endothelial cells have not been reported to have tuftsin receptors, they have never been excluded from having them either. It should be pointed out also that angiogenesis is closely linked with inflammation, and therapies that inhibit or enhance angiogenesis can inhibit or enhance inflammation (29-31), so some tuftsin effects attributed to inflammation may have in fact involved endothelial cells and angiogenesis. Based on this, it is possible that the reported uptake of a radiolabeled TKPPR derivative by arthritic tissues in an imaging study by Caveliers et al. (32) reflected angiogenesis in those tissues in addition to, or in place of, inflammation.