Regular ArticleModulation of Benzo[a]pyrene Bioactivation by Glucuronidation in Lymphocytes and Hepatic Microsomes from Rats with a Hereditary Deficiency in Bilirubin UDP-Glucuronosyltransferase
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Comparative study of the reproductive toxicity and modulation of enzyme activities by crude oil-contaminated soil before and after bioremediation
2022, ChemosphereCitation Excerpt :Soil contamination by crude oil spillage destroys the quality of the soil and renders it unfit for agricultural practices. Some compounds in crude oil are known to be mutagenic, genotoxic, carcinogenic, neurotoxic, haematotoxic, and immunotoxic (Hu and Wells, 1994; Hallier et al., 1995), and if not properly handled, can enter the water, streams, lakes, soil, and air (Adeniyi and Afolabi, 2002). Several methods such as physical, chemical, and biological methods have been employed to counter oil spillage in affected areas.
Inflammation and the chemical carcinogen benzo[a]pyrene: Partners in crime
2017, Mutation Research - Reviews in Mutation ResearchCitation Excerpt :Thirty-one UGT genes have been identified in human [80]. Without UGTs, several environmental carcinogens may further oxidate to their toxic reactive intermediates that can react with cellular macromolecules, thereby leading to toxicity [81]. Indeed, Hu and Wells (1992) showed with experiments in rats that had a genetic deficiency in bilirubin conjugating UGTs, that the glucuronidation of B[a]P metabolites was decreased, the level of B[a]P that covalently bound to hepatic DNA and microsomal proteins was increased, and that the B[a]P induced embryo toxicity was enhanced [82].
Redox cycling of 9,10-phenanthraquinone to cause oxidative stress is terminated through its monoglucuronide conjugation in human pulmonary epithelial A549 cells
2008, Free Radical Biology and MedicineCitation Excerpt :In contrast to PQH2, which has a redox-active potency as well as PQ [16], PQHG has neither cytotoxicity nor redox activity (Fig. 5). It has been reported that glucuronidation of phenols and quinols of toxic polycyclic aromatic hydrocarbons plays a protective role against their toxicity [35–37]. The results of this study demonstrate that the monoglucuronide of PQH2 is devoid of redox activity, so although PQ and its secondary metabolite PQH2 cause oxidative stress, formation of PQHG results in detoxification and rapid elimination from the cell.
cDNA cloning and characterization of feline CYP1A1 and CYP1A2
2006, Life SciencesModulation of adult rat benzo(a)pyrene (BaP) metabolism and DNA adduct formation by neonatal diethylstilbestrol (DES) exposure
2004, Experimental and Toxicologic PathologyNatural and synthetic inhibitors of UDP-glucuronosyltransferase
2001, Pharmacology and Therapeutics