Regular ArticleModulation of Gene and Protein Expression by Carbon Tetrachloride in the Rat Liver
References (42)
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding
Anal Biochem
(1976)- et al.
Induction of early-immediate genes by tumor necrosis factor alpha contribute to liver repair following chemical-induced hepatotoxicity
Hepatology
(1997) - et al.
RNA expression in the early characterization of hepatotoxicants in Wistar rats by high-density DNA microarrays
Hepatology
(2001) - et al.
G2 subpopulation in rat liver induced into mitosis by low-level exposure to carbon tetrachloride: an adaptive response
Toxicol. Appl. Pharmacol.
(1993) - et al.
Selective protein covalent binding and target organ toxicity
Toxicol. Appl. Pharmacol.
(1997) - et al.
Serum and liver concentrations of tumor necrosis factor alpha and interleukin-1beta following administration of carbon tetrachloride to male rats
Toxicol. Lett.
(1998) - et al.
The involvement of Kupffer cells in carbon tetrachloride toxicity
Toxicol. Appl. Pharmacol.
(1993) - et al.
Identification of proteins by matrix-assisted laser desorption ionization-mass spectrometry following in-gel digestion in low-salt, nonvolatile buffer and simplified peptide recovery
Anal. Biochem.
(1997) - et al.
Impaired mitochondrial function in microvesicular steatosis. Effects of drugs, ethanol, hormones and cytokines
J. Hepatol.
(1997) - et al.
Gene regulation of senescence marker protein-30 (SMP30): Coordinated up-regulation with tissue maturation and gradual down-regulation with aging
Mech. Ageing Dev.
(1996)
Differential induction and regulation of peroxisomal enzymes: Predictive value of peroxisome proliferation in identifying certain nonmutagenic carcinogens
Toxicol. Appl. Pharmacol.
Expression profiling of acetaminophen liver toxicity in mice using microarray technology
Biochem. Biophys. Res. Commun.
Protective effects of calcium channel blockers in carbon tetrachloride-induced liver toxicity
Life Sci.
Aging effects on hepatic NADPH cytochrome P450 reductase, CYP2B1&2, and polymeric immunoglobulin receptor mRNAs in male Fischer 344 rats
Exp. Gerontol.
Microarray analysis of hepatotoxins in vitro reveals a correlation between gene expression profiles and mechanisms of toxicity
Toxicol. Lett.
Increased muscle protein catabolism caused by carbon tetrachloride hepatic injury in rats
Gastroenterology
Expression of matrix metalloproteinase-13 and tissue inhibitor of metalloproteinase-1 in acute liver injury
J. Hepatol.
Unique gene expression patterns in liver and kidney associated with exposure to chemical toxicants
J. Pharmacol. Exp. Ther.
Reliable automatic protein identification from matrix-assisted laser desorption/ionization mass spectrometric peptide fingerprints
Electrophoresis
Identification of glutathione S-transferase isozymes and gamma-glutamylcysteine synthetase as negative acute-phase proteins in rat liver
Hepatology
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2022, International Journal of Biological MacromoleculesCitation Excerpt :Protein modulation may be acquired or induced to understand aetiology of various diseases. Modulation in proteins has also been documented during early and recovery phases of experimental hepatic injury in rats [1,2]. These proteomic adjustments reflect a concerted and intricate response by the body during restitution of liver injury.
The potential of metabolomic approaches for investigating mode(s) of action of xenobiotics: Case study with carbon tetrachloride
2011, Mutation Research - Genetic Toxicology and Environmental MutagenesisCitation Excerpt :They also observed a differential expression of genes of transforming growth factor-beta (TGF-β) and the inflammatory response pathways. Similarly, other studies [93] have shown up-regulation of stress defense proteins (e.g. catalase and uricase) and down-regulation of enzymes involved in lipid and amino acid metabolism and with a dramatic increase in the expression of stress and DNA-damage and DNA-repair-related genes (e.g. GADD45) in rats given a single injection of CCl4. Together, these results suggest that the metabolomics data can be integrated with proteomics, genomics and transcriptomics data [94].
Simultaneous application of t-test and fold change criteria to identify acetaminophen and carbon tetrachloride affected genes in mice liver
2008, Environmental Toxicology and PharmacologyCitation Excerpt :In spite of the high stringency criteria used in this study, that permitted identification of very few probes, a good correlation was found with previous studies. Typically, a single dose of CCl4 results in centrilobular cell degeneration and necrosis accompanied by lipid peroxidation along with elevated serum enzyme activities followed by hepatic regeneration, usually starting after 48 h (Fountoulakis et al., 2002). Correspondingly, expression of mRNA in hepatic parenchyma cells generally changes on exposure to a single toxic dose of compound.
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