Skip to main content
SpringerLink
Log in

PHARMACOKINETICS AND PHARMACODYNAMICS OF CURCUMIN

  • Chapter
Book cover The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease

Part of the book series: ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY ((AEMB,volume 595))

Abstract

Curcuma spp. contain turmerin, essential oils, and curcuminoids, including curcumin. Curcumin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6- heptadiene-3,5-dione] is regarded as the most biologically active constituent of the spice turmeric and it comprises 2–8% of most turmeric preparations. Preclinical data from animal models and phase I clinical studies performed with human volunteers and patients with cancer have demonstrated low systemic bioavailability following oral dosing.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 169.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 219.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. 1. B. Brouk, Plants Consumed by Man. New York: Academic Press, 1975, p. 331.

    Google Scholar 

  2. 2. D. Eigner and D. Sholz, Ferula asa–foetida and curcuma longa in traditional medical treatment and diet in Nepal. J Ethnopharmacol 67, 1–6 (1999).

    Article  PubMed  CAS  Google Scholar 

  3. 3. J. Milobedzka, V. Kostanecki, and V. Lampe, Structure. Chem Ber 43, 2163 (1910).

    Article  CAS  Google Scholar 

  4. 4. D. D. Heath, F. Khwaja, and C. L. Rock, Curcumin content of turmeric and curry powders. FASEB J 18, A125 (2004).

    Google Scholar 

  5. 5. H. P. Ammon and M. A. Wahl, Pharmacology of curcuma longa. Planta Med 57, 1–7 (1991).

    Article  PubMed  CAS  Google Scholar 

  6. 6. B. B. Aggarwal, A. Kumar, and A. C. Bharti, Anticancer potential of curcumin: Preclinical and clinical studies. Anticancer Res 23, 363–398 (2003).

    PubMed  CAS  Google Scholar 

  7. 7. B. Joe, M. Vijaykumar, and B. R. Lokesh, Biological properties of curcumin: Cellular and molecular mechanisms of action. Crit Rev Food Sci Nutr 44, 97–111 (2004).

    Article  PubMed  CAS  Google Scholar 

  8. 8. B. Wahlstrom and G. Blennow, A study on the fate of curcumin in the rat. Acta Pharmacol Toxicol 43, 86–92 (1978).

    Article  CAS  Google Scholar 

  9. 9. V. Ravindranath and N. Chandrasekhara, Absorption and tissue distribution of curcumin in rats. Toxicology 16, 259–265 (1980).

    Article  PubMed  CAS  Google Scholar 

  10. 10. V. Ravindranath and N. Chandrasekhara, In vitro studies on the intestinal absorption of curcumin in rats. Toxicology 20, 251–257 (1981).

    Article  PubMed  CAS  Google Scholar 

  11. 11. V. Ravindranath and N. Chandrasekhara, Metabolism of curcumin: Studies with [3H] curcumin. Toxicology 22, 337–344 (1981).

    Article  PubMed  Google Scholar 

  12. 12. G. M. Holder, J. L. Plummer, and A. J. Ryan, The metabolism and excretion of curcumin [1,7-bis-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] in the rat. Xenobiotica 8, 761–768 (1978).

    PubMed  CAS  Google Scholar 

  13. 13. M. H. Pan, T. M. Huang, and J. K. Lin, Biotransformation of curcumin through reduction and glucuronidation in mice. Drug Metab Dispos 27, 486–494 (1999).

    PubMed  CAS  Google Scholar 

  14. 14. C. Ireson, S. Orr, D. J. L. Jones, et al., Characterization of metabolites of the chemopreventive agent curcumin in humans and rat hepatocytes and in the rat in vivo, and evaluation of their ability to inhibit phorbol ester-induced prostaglandin E2 production. Cancer Res 61, 1058–1064 (2001).

    PubMed  CAS  Google Scholar 

  15. 15. C R. Ireson, D. J. L. Jones, S. Orr, M. W. H. Coughtrie, D. Boocock, M. L. Williams, P. B. Farmer, W. P. Steward, and A. J. Gescher, Metabolism of the cancer chemopreventive agent curcumin in human and rat intestine. Cancer Epidemiol Biomarkers Prev 11, 97–104 (2002).

    Google Scholar 

  16. 16. R. A. Sharma, C. R. Ireson, R. D. Verschoyle, et al., Effects of dietary curcumin on glutathione S-transferase and malondialdehyde-DNA adducts in rat liver and colon mucosa: Relationship with drug levels. Clin Cancer Res 7, 1452–1458 (2001).

    PubMed  CAS  Google Scholar 

  17. 17. G. Shoba, D. Joy, T. Joseph, M. Majeed, R. Rajendran, and P. S. S. R. Srinivas, Influence of piperine on the pharmacokinetics of curcumin in animals and human volunteers. Planta Med 64, 353–356 (1998).

    Article  PubMed  CAS  Google Scholar 

  18. 18. A. L. Cheng, C, H. Hsu, J. K. Lin, et al., Phase I clinical trial of curcumin, a chemopreventive agent, in patients with high-risk or pre-malignant lesions. Anticancer Res 21, 2895–2900 (2001).

    PubMed  CAS  Google Scholar 

  19. 19. M. T. Ruffin, D. P. Normolle, D. D. Heath, J. M. Bailey, S. I. Murray, M. E. Boggs, J. A. Crowell, C. L. Rock, and D. E. Brenner, Dose escalation of curcumin in healthy adults. Cancer Epidemiol Biomarkers Prev 12(Pt 2 Suppl S), 1324S–1324S (2003).

    Google Scholar 

  20. 20. R. A. Sharma, H. R. McLelland, K. A. Hill, et al., Pharmacodynamic and pharmacokinetic study of oral Curcuma extract in patients with colorectal cancer. Clin Cancer Res 7, 1894–1900 (2001).

    PubMed  CAS  Google Scholar 

  21. 21. R. A. Sharma, S. A. Euden, S. L. Platton, et al., Phase I clinical trial of oral curcumin: Biomarkers of systemic activity and compliance. Clin Cancer Res 10, 6847–6854 (2004).

    Article  PubMed  CAS  Google Scholar 

  22. 22. G. Garcea, D. P. Berry, D. J. L. Jones, et al., Consumption of the putative chemopreventive agent curcumin by cancer patients: Assessment of curcumin levels in the colorectum and their pharmacodynamic consequences. Cancer Epidemiol Biomarkers Prev 14, 120–125 (2005).

    PubMed  CAS  Google Scholar 

  23. 23. G. Garcea, D. J. L. Jones, R. Singh, et al., Detection of curcumin and its metabolites in hepatic tissue and portal blood of patients following oral administration. Br J Cancer 90, 1011–1015 (2004).

    Article  PubMed  CAS  Google Scholar 

  24. 24. NCI, DCPC, Clinical development plan: Curcumin. J Cell Biochem 26S, 72–85 (1996).

    Google Scholar 

  25. 25. C. V. Rao, A. Rivenson, B. Simi, and B. S. Reddy, Chemoprevention of colon carcinogenesis by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res 55, 259–266 (1995).

    PubMed  CAS  Google Scholar 

  26. 26. K. B. Soni, A. Rajan, and R. Kuttan, Reversal of aflatoxin induced liver damage by turmeric and curcumin. Cancer Lett 66, 115–121 (1992).

    Article  PubMed  CAS  Google Scholar 

  27. 27. T. Kawamori, R. Lubet, V. E. Steele, et al., Chemopreventative effect of curcumin, a naturally occurring anti-inflammatory agent, during the promotion/progression stages of colon cancer. Cancer Res 59, 597–601 (1999).

    PubMed  CAS  Google Scholar 

  28. 28. H. S. Samaha, G. J. Kelloff, V. Steele, C. V. Rao, and B. S. Reddy, Modulation of apoptosis by sulindac, curcumin, phenylethyl-3-methylcaffeate, and 6-phenylhexyl isothiocyanate, Apoptotic index as a biomarker in colon cancer chemoprevention and promotion. Cancer Res 57, 1301–1305 (1997).

    PubMed  CAS  Google Scholar 

  29. 29. S. R. Volate, D. M. Davenport, S. J. Muga, and M. Wargovich, Modulation of aberrant crypt foci and apoptosis by dietary herbal supplements (quercetin, curcumin, silymarin, ginseng and rutin). Carcinogenesis 26, 1450–1456 (2005).

    Article  PubMed  CAS  Google Scholar 

  30. 30. C. Luongo, A. R. Moser, S. Gledhill, and W. F Dove, Loss of Apc(+) in intestinal adenomas from Min mice. Cancer Res 54, 5947–5952 (1994).

    PubMed  CAS  Google Scholar 

  31. 31. S. Perkins, R. D. Verschoyle, K. A. Hill, I. Parveen, M. D. Threadgill, R. A. Sharma, M. L. Williams, W. P. Steward, and A. J. Gescher, Chemopreventive efficacy and pharmacokinetics of curcumin in the Min/+ mouse, a model of familial adenomatous polyposis. Cancer Epidemiol Biomarkers Prev 11, 535–540 (2002).

    PubMed  CAS  Google Scholar 

  32. 32. R. G. Tunstall, R. A. Sharma, S. Perkins, S. Sale, R. Singh, P. B. Farmer, W. P. Steward, and A. J. Gescher, Cyclooxygenase-2 expression and oxidative DNA adducts in murine intestinal adenomas: Modification by dietary curcumin and implications for clinical trials. Eur J Cancer 42, 415–421 (2006).

    Article  PubMed  CAS  Google Scholar 

  33. 33. A. H. Conney, Enzyme induction and dietary chemicals as approaches to cancer chemoprevention: The seventh DeWitt S. Goodman Lecture. Cancer Res 63, 7005–7031 (2003).

    PubMed  CAS  Google Scholar 

  34. 34. N. Li, X. Chen, J. Liao, et al. Inhibtion of 7,12-dimethylbenz[a]anthracene (DMBA)-induced oral carcinogenesis in hamsters by tea and curcumin. Carcinogenesis 23, 1307–1313 (2002).

    Article  PubMed  CAS  Google Scholar 

  35. 35. K. Imaida, S. Tamano, K. Kato, Y. Ikeda, M. Asamoto, S. Takahashi, Z. Nir, M. Murakoshi, H. Nishino, and T. Shirai, Lack of chemopreventive effects of lycopene and curcumin on experimental rat prostate carcinogenesis. Carcinogenesis 22, 467–472 (2001).

    Article  PubMed  CAS  Google Scholar 

  36. 36. B. B. Aggarwal, S. Shishodia, Y. Takada, S. Banerjee, R. A. Newman, C. E. Bueso-Ramos, and J. E. Price, Curcumin suppresses the paclitaxel-induced nuclear factor-κ B pathway in breast cancer cells and inhibits lung metastasis of human breast cancer in nude mice. Clin Cancer Res 11, 7490–7498 (2005).

    Article  PubMed  CAS  Google Scholar 

  37. 37. S. V. Bava, V. T. Puliappadamba, A. Deepti, A. Nair, D. Karunagaran, and R. J. Anto, Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-κ B and the serine/threonine kinase Akt and is independent of tubulin polymerization. J Biol Chem 280, 6301–6308 (2005)

    Article  PubMed  CAS  Google Scholar 

  38. 38. Y. Shukla, A. Arora, and P. Taneja, Antimutagenic potential of curcumin on chromosomal aberrations in Wistar rats. Mutat Res: Genet Toxicol Environ Mutag 515, 197–202 (2002).

    Article  CAS  Google Scholar 

  39. 39. M. E. Egan, M. Pearson, S. A. Weiner, et al., Curcumin, a major constituent of turmeric, corrects cystic fibrosis defects. Science 304, 600–602 (2004).

    Article  PubMed  CAS  Google Scholar 

  40. 40. S. V. Singh, X. Hu, S. K. Srivastava, et al., Mechanism of inhibition of benzo[a]pyrene-induced forestomach cancer in mice by dietary curcumin. Carcinogenesis 19, 1357–1360 (1998).

    Article  PubMed  CAS  Google Scholar 

  41. 41. M. Susan and M.A. Rao, Induction of glutathione S-transferase activity by curcumin in mice. Drug Res 42, 962–964 (1992).

    CAS  Google Scholar 

  42. 42. J. T. Piper, S. S. Singhal, M. Salameh, R. T. Torman, Y. C. Awasthi, and S. Awasthi, Mechanisms of anticarcinogenic properties of curcumin: The effect of curcumin on glutathione linked detoxification enzymes in rat liver. Int J Biochem Cell Biol 30, 445–456 (1998).

    Article  PubMed  CAS  Google Scholar 

  43. 43. W. A. Nijhoff, G. M. Groen, and W. H. M. Peters, Induction of rat hepatic and intestinal glutathione S-transferases and glutathione by dietary naturally occurring anticarcinogens. Int J Oncol 3, 1131–1139 (1993).

    CAS  Google Scholar 

  44. 44. A. T. Dinkova-Kostova and P. Talalay, Relation of structure of curcumin analogs to their potencies as inducers of Phase 2 detoxification enzymes. Carcinogenesis 20, 911–914 (1999).

    Article  PubMed  CAS  Google Scholar 

  45. 45. J. D. Hayes and D. J. Pulford, The glutathione S-transferases supergene family. Crit Rev Biochem Mol Biol 30, 445–600 (1995).

    PubMed  CAS  Google Scholar 

  46. 46. A. Duvoix, S. Delhalle, R. Blasius, et al., Effect of chemopreventive agents on glutathione S-transferase P1-1 gene expression mechanisms via activating protein 1 and nuclear factor κB inhibition. Biochem Pharmacol 68, 1101–1111 (2004).

    Article  PubMed  CAS  Google Scholar 

  47. 47. P. K. Lala and C. Chakraborty, Role of nitric oxide in carcinogenesis and tumour progression. Lancet Oncol 2, 149–156 (2001).

    Article  PubMed  CAS  Google Scholar 

  48. 48. T. deRojas-Walker, S. Tamir, H. Ji, J. S. Wishnok, and S. R. Tannenbaum, Nitric oxide induces oxidative damage in addition to deaminiation in macrophage DNA. Chem Res Toxicol 8, 473–477 (1995).

    Article  PubMed  CAS  Google Scholar 

  49. 49. M. Graziewicz, D. A. Wink, and F. Laval, Nitric oxide inhibits DNA ligase activity: Potential mechanisms for NO-mediated DNA damage. Carcinogenesis 17, 2501–2505 (1996).

    Article  PubMed  CAS  Google Scholar 

  50. 50. S. Ambs, W. P. Bennett, W. G. Merrium, et al., Relationship between p53 mutations and inducible nitric oxide synthase expression in human colorectal cancer. J Natl Cancer Inst 91, 86–88; reply 1510–1511 (1999).

    PubMed  Google Scholar 

  51. 51. A. Von Knethen and B. Brune B, Cyclooxygenase-2: An essential regulator of NO-mediated apoptosis. FASEB J 11, 887–895 (1997).

    Google Scholar 

  52. 52. A. Von Knethen, D. Callsen, and B. Brune, NF-κB and AP-1 activation by nitric oxide attenuated apoptotic death in RAW 264.7 macrophages. Mol Biol Cell 10, 361–370 (1999).

    Google Scholar 

  53. 53. I. Brouet and H. Ohshima, Curcumin, an anti-tumour promoter and anti-inflammatory agent, inhibits induction of nitric oxide synthase in activated macrophages. Biochem Biophys Res Commun 206, 533–540 (1995).

    Article  PubMed  CAS  Google Scholar 

  54. 54. M. M. Chan, H. I. Huang, M. R. Fenton, and D. Fong, In vivo inhibition of nitric oxide synthase gene expression by curcumin, a cancer preventive natural product with anti-inflammatory properties. Biochem Pharmacol 55, 1955–1962 (1998).

    Article  PubMed  CAS  Google Scholar 

  55. 55. A. Raysid and A. Lelo, The effect of curcumin and placebo on human gall-bladder function: An ultrasound study. Aliment Pharmacol Ther 13, 245–249 (1999).

    Article  Google Scholar 

  56. 56. S. M. Plummer, K. A. Hill, M. F. W. Festing, W. P. Steward, A. J. Gescher, and R. A. Sharma, Clinical development of leukocyte cyclooxygenase 2 activity as a systemic biomarker for cancer chemopreventive agents. Cancer Epidemiol Biomarkers Prev 10, 1295–1299 (2001).

    PubMed  CAS  Google Scholar 

  57. 57. S. M. Plummer, K. A. Holloway, M. M. Manson, et al., Inhibition of cyclo-oxygenase 2 expression in colon cells by the chemopreventive agent curcumin involves inhibition of NF-κB activation via the NIK/IKK signalling complex. Oncogene 18, 6013–6020 (1999).

    Article  PubMed  CAS  Google Scholar 

  58. 58. F. Zhang, N. K. Altorki, J. R. Mestre, et al., Curcumin inhibits cyclooxygenase-2 transcription in bile acid- and phorbol ester-treated human gastrointestinal epithelial cells. Carcinogenesis 20, 445–451 (1999).

    Article  PubMed  CAS  Google Scholar 

  59. 59. A. C. Bharti, N. Donato, and B. B. Aggarwal, Curcumin (diferuloylmethane) inhibits constitutive and IL-6-inducible STAT3 phosphorylation in human multiple myeloma cells. J Immunol 171, 3863–3871 (2003).

    PubMed  CAS  Google Scholar 

  60. 60. K. Sugimoto, H. Hanai, K. Tozawa, et al., Curcumin prevents and ameliorates trinitrobenzene sulfonic acid-induced colitis in mice. Gastroenterology 123, 1912–1922 (2002).

    Article  PubMed  CAS  Google Scholar 

  61. 61. R. R. Satoskar, S. J. Shah, and S. G. Shenoy, Evaluation of anti-inflammatory property of curcumin (diferuloyl methane) in patients with post-operative inflammation. Int J Clin Pharmacol Ther Toxicol 24, 651–654 (1986).

    PubMed  CAS  Google Scholar 

  62. 62. S. D. Deodhar, R. Sethi, and R. C. Srimal, Preliminary study on antirheumatic activity of curcumin (diferuloyl methane). Indian J Med Res 71, 632–634 (1980).

    PubMed  CAS  Google Scholar 

  63. 63. P. R. Holt, S. Katz, and R. Kirshoff, Curcumin therapy in inflammatory bowel disease: A pilot study. Dig Dis Sci 11, 2191–2193 (2005).

    Article  Google Scholar 

  64. 64. B. Lal, A. K. Kapoor, O. P. Asthana, et al., Efficacy of curcumin in the managememtn of chronic anterior uveitis. Phytother Res 13, 318–322 (1999).

    Article  PubMed  CAS  Google Scholar 

  65. 65. B. Lal, A. K. Kapoor, P. K. Agrawal, et al., Role of curcumin in idiopathic inflammatory orbital pseudotumours. Phytother Res 14, 443–447 (2000).

    Article  PubMed  CAS  Google Scholar 

  66. 66. R. Kuttan, P. C. Sudheeran, and C. D. Josph, Turmeric and curcumin as topical agents in cancer therapy. Tumori 73, 29–31 (1987).

    PubMed  CAS  Google Scholar 

  67. 67. W. H. Chan and H. Wu, Anti-apoptotic effects of curcurnin on photosensitized human epidermal carcinoma A431 cells. J Cell Biochem 92, 200–212 (2004).

    Article  PubMed  CAS  Google Scholar 

  68. 68. M. C. Jiang, H. F. Yang Yen, J. J. Y. Yen, et al., Curcumin induces apoptosis in immortalized NIH 3T3 and malignant cancer cell lines. Nutr Cancer 26, 111–120 (1996).

    Article  PubMed  CAS  Google Scholar 

  69. 69. C. H. Yan, M. S. Jamaluddin, B. Aggarwal, J. Myers, and D.D. Boyd, Gene expression profiling identifies activating transcription factor 3 as a novel contributor to the proapoptotic effect of curcumin. Mol Cancer Therapeut. 4, 233–241 (2005).

    CAS  Google Scholar 

  70. 70. M. L. Kuo, T. S. Huang, and J. K. Lin, Curcumin, an antioxidant and anti-tumor promoter, induces apoptosis in human leukemia cells. Biochim Biophys Acta 1317, 95–100 (1996).

    PubMed  CAS  Google Scholar 

  71. 71. G. P. Collett and F. C. Campbell, Curcumin induces c-jun N-terminal kinase-dependent apoptosis in HCT116 human colon cancer cells. Carcinogenesis 25, 2183–2189 (2004).

    Article  PubMed  CAS  Google Scholar 

  72. 72. M. M. Y. Chan, Inhibition of tumor necrosis factor by curcumin, a phytochemical. Biochem Pharmacol 49, 1551–1556 (1995).

    Article  PubMed  CAS  Google Scholar 

  73. 73. Y. Abe, S. Hashimoto, and T. Horie, Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol Res 39, 41–47 (1999).

    Article  PubMed  CAS  Google Scholar 

  74. 74. B. Gupta and B. Ghosh, Curcuma longa inhibits TNF-alpha induced expression of adhesion molecules on human umbilical vein endothelial cells. Int J Immnopharmacol 21, 745–757 (1999).

    Article  CAS  Google Scholar 

  75. 75. Y. Moon, W. C. Glasgow, and T. E. Eling, Curcumin suppresses interleukin 1 beta-mediated microsomal prostaglandin E synthase 1 by altering early growth response gene 1 and other signaling pathways. J Pharmacol Exp Ther 315, 788–795 (2005).

    Article  PubMed  CAS  Google Scholar 

  76. 76. E. Balogun, M. Hoque, P. F. Gong, E. Killeen, C. J. Green, R. Foresti, J. Alam, and R. Motterlini, Curcurmin activates the haem oxygenase-1 gene via regulation of Nrf2 and the antioxidant-responsive element. Biochem J 371, 887–895 (2003).

    Article  PubMed  CAS  Google Scholar 

  77. 77. C. K. Andreadi, L. M. Howells, P. A. Atherfold, and M. M. Manson, Involvement of Nrf2, p38, B-Raf, and nuclear factor-κ B, but not phosphatidylinositol 3-kinase, in induction of hemeoxygenase-1 by dietary polyphenols. Mol Pharmacol 69, 1033–1040 (2006).

    PubMed  CAS  Google Scholar 

  78. 78. P. F. Firozi, V. S. Aboobaker, and R. K. Bhattacharya, Action of curcumin on the cytochrome P450-system catalyzing the activation of aflatoxin B1. Chem-Biol Interact 100, 41–51 (1996).

    Article  PubMed  CAS  Google Scholar 

  79. 79. H. P. Ciolino, P. J. Daschner, T. T. Wang, and G. C. Yeh, Effect of curcumin on the aryl hydrocarbon receptor and cytochrome P450 1A1 in MCF-7 human breast carcinoma cells. Biochem Pharmacol 56, 197–206 (1998).

    Article  PubMed  CAS  Google Scholar 

  80. 80. M. S. Woo, S. H. Jung, S. Y. Kim, J. W. Hyun, K. H. Ko, W. K. Kim, and H. S. Kim, Curcumin suppresses phorbol ester-induced matrix metalloproteinase-9 expression by inhibiting the PKC to MAPK signaling pathways in human astroglioma cells. Biochem Biophys Res Commun 335, 1017–1025 (2005).

    Article  PubMed  CAS  Google Scholar 

Download references

Authors
  1. Ricky A. Sharma
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. William P. Steward
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Andreas J. Gescher
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Ransom Horne, Jr., Professor of Cancer Research Professor of Cancer Medicine (Biochemistry)and Chief, Cytokine Research Section Department of Experimental Therapeutics, The University of Texas M. D. Anderson Cancer Center, 1515 Holcombe Boulevard, Houston,, TX, 143, 77030, USA

    Bharat B. Aggarwal Ph.D.

  2. Chief and Professor National Research Laboratory of Molecular Carcinogenesis and Chemoprevention College of Pharmacy, Seoul National University, Shillim-dong, Kwanak-gu, Seoul, 151-742, South Korea

    Young-Joon Surh Ph.D.

  3. Assistant Professor Department of Biology, Texas Southern University, 3100 Cleburne Street, Houston, TX 77004, USA

    Shishir Shishodia Ph.D.

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer

About this chapter

Cite this chapter

Sharma, R.A., Steward, W.P., Gescher, A.J. (2007). PHARMACOKINETICS AND PHARMACODYNAMICS OF CURCUMIN. In: Aggarwal, B.B., Surh, YJ., Shishodia, S. (eds) The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY, vol 595. Springer, Boston, MA. https://doi.org/10.1007/978-0-387-46401-5_20

Download citation

Publish with us

Policies and ethics

Search

Navigation