Summary
The acute effects of oral administration of felodipine 10 mg and nifedipine 10 mg on heart rate, blood pressure, forearm blood flow and hepatic blood flow were studied in nine healthy men.
Both drugs caused an increase in heart rate of 16 and 7 beats · min−1, respectively. Hepatic blood flow was significantly increased by 1.2 and 0.41 · min−1 after felodipine and nifedipine. There was also a decrease in diastolic blood pressure, 10 and 5 mm Hg, respectively, after felodipine and nifedipine. The forearm blood flow was increased by about 30 ml · 100 ml−1 · min−1 after felodipine, but nifedipine had no effect.
The haemodynamic effects were most pronounced 50 min after drug administration.
Similar content being viewed by others
References
Ahnoff M (1984) Determination of felodipine in plasma by capillary gas chromatography with electron capture detection. J Pharm Biomed Anal 2: 519–526
Caesar J, Shaldon S, Chiandussi L, Guevara L, Sherlock S (1961) The use of indocyanine green in the measurement of hepatic blood flow and as a test of hepatic function. Clin Sci 21: 43–57
Carlsten A, Nilsson NJ, Thuesius O (1967) Methods for examination of the peripheral circulation. In: Sjöstrand (ed) Clinical physiology. Norstedts-Bonniers, Stockholm, pp 397–412
Feely J (1984) Nifedipine increases and glyceryl trinitrate decreases apparent liver blood flow in normal subjects. Br J Clin Pharmacol 17: 83–85
George CF (1979) Drug kinetics and hepatic blood flow. Clin Pharmacokinet 4: 433–448
Johnsson G, Murray G, Tweddel A, Hutton I (1983) Hemodynamic effects of a new vasodilator drug, felodipine, in healthy subjects. Eur J Clin Pharmacol 24: 49–53
Kleinbloesem CH, van Brummelen P, van de Linde JA, Voogd PJ, Breimer DD (1984) Nifedipine: Kinetics and dynamics in healthy subjects. Clin Pharmacol Ther 35 [Suppl 6]: 742–749
Lederballe-Pedersen O, Christiansen NJ, Rämsch KD (1980) Comparison of acute effects of nifedipine in normotensive and hypertensive man. J Cardiovasc Pharmacol 2: 357–366
Ljung B (1985) Vascular selectivity of felodipine. Drugs 29 [Suppl 2]: 46–58
Lund Johansen P, Omvik P (1983) Hemodynamic effects of nifedipine in essential hypertension at rest and during exercise. J Hypertens 1: 159–163
Magorien RD, Triffon DW, Desch CE, Bay WH, Unverferth DV, Leier CV (1981) Prazosin and hydralazine in congestive heart failure. Ann Intern Med 95: 5–13
Meredith PA, Pasanisi F, Elliott HL, Reid JL (1985) The effect of nisoldipine on apparent liver blood flow and effective renal plasma flow. Br J Clin Pharmacol 20: 235–237
Meredith PA, Pasanisi F, Elliott HL, Kelman AW, Sumner DJ, Reid JL (1985) Verapamil pharmacokinetics and apparent hepatic and renal blood flow. Br J Clin Pharmacol 20: 101–106
Pasanisi F, Elliott HL, Meredith PA, McSharry DR, Reid JL (1984) Combined alpha adrenoceptor antagonism and calcium channel blockade in normal subjects. Clin Pharmacol Ther 36 [Suppl 6]: 716–723
Rönn O, Bengtsson B, Edgar B, Raner S (1985) Acute haemodynamic effects of felodipine and verapamil in man, singly and with metoprolol. Drugs 29 [Suppl 2]: 16–25
Stenson RE, Constantino RT, Harrison DC (1971) Interrelationships of hepatic blood flow, cardiac output and blood levels of lidocaine in man. Circulation 43: 205–211
Svensson CK, Edwards DJ, Mauriello PM, Barde SH, Foster AC, Lanc RA, Middleton E, Lalka D (1983) Effect of food on hepatic blood flow: Implications in the “food effect” phenomenon. Clin Pharmacol Ther 34: 316–323
Whitney RJ (1953) The measurement of volume changes in human limbs. J Physiol 121: 1–27
Wiegand BD, Ketterer SG, Rapaport E (1960) The use of indocyanine green for the evaluation of hepatic function and blood flow in man. Am J Dig Dis 5: 427–436
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Bengtsson-Hasselgren, B., Rönn, O., Blychert, L.O. et al. Acute effects of felodipine and nifedipine on hepatic and forearm blood flow in healthy men. Eur J Clin Pharmacol 38, 529–533 (1990). https://doi.org/10.1007/BF00278576
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/BF00278576