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The binding of ibuprofen to plasma proteins

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Summary

The binding of ibuprofen to human serum albumin, normal plasma and plasma obtained from rheumatoid arthritic patients was studied using the method of ultracentrifugation. It was found that ibuprofen is more strongly bound to normal plasma than to human serum albumin although this result is probably explained by fatty acid contamination of the human serum albumin. The fraction of ibuprofen not bound to normal plasma rose significantly from a value of 0.0128 at an ibuprofen concentration of 2 mg·l−1 to 0.0155 at a concentration of 50 mg·l−1. Ibuprofen was less strongly bound to rheumatoid plasma than to normal plasma but this difference can be accounted for by the difference in albumin concentration between the two plasmas. It was found that salicylic acid can displace ibuprofen from protein binding sites, in vitro, and that this is the probable cause of the pharmacokinetic interaction between the two drugs.

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References

  1. Adams SS, Warwick-Butler J (1979) Ibuprofen and flurbiprofen. Clin Rheum Dis 5 [2]: 359–391

    Google Scholar 

  2. Rowland M (1980) Plasma protein binding and therapeutic drug monitoring. Ther Drug Monitor 2: 29–37

    Google Scholar 

  3. Mills RFN, Adams SS, Cliffe EE, Dickinson W, Nicholson JS (1973) The metabolism of ibuprofen. Xenobiotica 3: 589–598

    Google Scholar 

  4. Whitlam JB, Crooks MJ, Brown KF, Pedersen PV (1979) Binding of non-steroidal anti-inflammatory agents to proteins. I Ibuprofen-serum albumin interaction. Biochem Pharmacol 28: 675–678

    Google Scholar 

  5. Kober A, Sjöholm I (1980) The binding sites on human serum albumin for some nonsteroidal anti-inflammatory drugs. Molec Pharmacol 18: 421–426

    Google Scholar 

  6. Denko CW, Puser DB, Johnson RM (1970) Albumin amino acids in patients with rheumatoid arthritis. Arthritis Rheum 13: 311–312

    Google Scholar 

  7. Selley ML, Madsen BW, Thomas J (1978) Protein binding of tolmetin. Clin Pharmacol Ther 24: 694–705

    Google Scholar 

  8. Vowles DT, Marchant B (1980) Protein binding of ibuprofen and its relationship to drug interactions. Br J Clin Pract 6 [Symp Suppl]: 13–19

    Google Scholar 

  9. Wanwimolruk S, Birkett DJ, Brooks PM (1982) Protein binding of some nonsteroidal anti-inflammatory durgs in rheumatoid arthritis. Clin Pharmacokinet 7: 85–92

    Google Scholar 

  10. Grennan DM, Ferry, DG, Ashworth ME, Kenny RE, Mackinnon M (1979) The aspirin-ibuprofen interaction in rheumatoid arthritis. Br J Clin Pharmacol 8: 497–503

    Google Scholar 

  11. Wilkinson GR, Shand DG (1975) A physiological approach to hepatic drug clearance. Clin Pharmacol Ther 18: 377–384

    Google Scholar 

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Aarons, L., Grennan, D.M. & Siddiqui, M. The binding of ibuprofen to plasma proteins. Eur J Clin Pharmacol 25, 815–818 (1983). https://doi.org/10.1007/BF00542526

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  • DOI: https://doi.org/10.1007/BF00542526

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