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Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine

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Summary

Two subjects from each of the three groups of homozygous rapid, heterozygous, and homozygous non-metabolizers (N-oxidation) of sparteine received a single oral dose of debrisoquine. The urinary ratio of debrisoquine/4-hydroxy-debrisoquine, reflecting the individual's capacity to C-hydroxylate debrisoquine, was closely related to his phenotype for sparteine metabolism. This indicates that the two metabolic reactions are controlled by similar if not identical genetic factors.

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Authors and Affiliations

  1. Department of Clinical Pharmacology, Karolinska Institutet, Huddinge Hospital, Huddinge, Sweden

    L. Bertilsson, H. J. Dengler, M. Eichelbaum & H. -U. Schulz

  2. Department of Medicine, University of Bonn, Bonn-Venusberg, Federal Republic of Germany

    L. Bertilsson, H. J. Dengler, M. Eichelbaum & H. -U. Schulz

Authors
  1. L. Bertilsson
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  2. H. J. Dengler
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  3. M. Eichelbaum
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  4. H. -U. Schulz
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At Karolinska Institutet on temporary leave from Department of Angiology and Geriatrics, Medical School of Lübeck, Federal Republic of Germany.

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Bertilsson, L., Dengler, H.J., Eichelbaum, M. et al. Pharmacogenetic covariation of defective N-oxidation of sparteine and 4-hydroxylation of debrisoquine. Eur J Clin Pharmacol 17, 153–155 (1980). https://doi.org/10.1007/BF00562624

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  • DOI: https://doi.org/10.1007/BF00562624

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