Summary
Noscapine was administred to five healthy volunteers in a randomized crossover design, as an intravenous infusion of 66 mg, and as an oral 150 mg dose of either rapidly dissolving tablets or a tablet containing ion exchange resin-bound noscapine. After i.v. administration, the disposition of noscapine was bi-exponential with an elimination half-life of 2.6 h; the total plasma clearance was 22 ml/min/kg and the volume of distribution (Vdarea) was 4.7 l/kg. The absolute oral bioavailability was 30%, with a 3.6-fold interindividual variation. There was no pharmacokinetic evidence to support a prolonged action of the ion exchange resin tablet.
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References
Chopra RN, Mukherjee BI, Dikshit BB (1930) Narcotine: its pharmacological action and therapeutic uses. Indian J Med Res 18:35–49
Winter CA, Flataker L (1954) Antitussive compounds testing methods and results. J Pharmacol Exp Ther 112:99–108
Bickerman HA, Barach AL (1954) The experimental production of cough in human subjects induced by citric acid aerosols. Preliminary studies on the evaluation of antitussive agents. Am J Med Sci 228:156–163
Bickerman HA, German E, Cohen BM, Itkin SE (1957) The cough response of healthy human subjects stimulated by citric acid aerosol. Part II. The evaluation of antitussive agents. Am J Med Sci 234:191–206
Empey EW, Laitinen LA, Young GA, Bye CE, Hughes DTD (1979) Comparison of the antitussive effects of codeine phosphate 20 mg, dextrometorphan 30 mg and noscapine 30 mg using citric acid-induced cough in normal subjects. Eur J Clin Pharmacol 16:393–397
Vedsö S (1961) Absorption and excretion of noscapine. Acta Pharmacol Toxicol 18:157–164
Nayak KP, Brochmann-Hanssen E, Leong Way E (1965) Biological disposition of noscapine. Pharm Sci 54:191–194
Gibaldi M, Weiner N (1966) Biphasic elimination of noscapine. J Pharm Sci 55:761–771
Pawelczyk E, Zajac M (1957) Kinetics of drug decomposition. Part 32. Kinetics and mechanism of hydrolysis of narcotine and lactonization of narcotic acid. Pol J Pharmacol Pharm 27:69–80
Pawelczyk E, Zajac M, Matlak B (1976) Kinetics of drug decomposition. Part 37. Kinetics of autoxidation of narcotine in aqueous solutions. Pol J Pharmacol Pharm 28:69–76
Johansson M, Arbin A, Ekensberg S (1982) Determination of noscapine in serum by liquid chromatography. J Pharm Sci (In press)
Loder RE (1969) Safe reduction of cough reflex with noscapine. Anaesthesia 24:355–358
Metzler CM, Elfring GL, Mc Ewen AJ (1974) A package of computer programs for pharmacokinetic modeling Biometrics, 30:562–563
Dixon WJ (1979) BMDP-79, Biomedical computer programs P-series. University of California Press, Berkeley
Tsunoda N, Yoshimura H (1979) Metabolic fate of noscapine. II. Isolation and identification of novel metabolites produced by C-C bond cleavage. Xenobiotica 3:181–187
Wulff O (1965) Prolonged antitussive action of a resin-bound noscapine preparation. J Pharm Sci 54:1058–1060
Wilkinson GR, Shand DG (1975) A physiological approach to hepatic drug clearance. Clin Pharmacol Ther 18:377–390
Lasagna L, Owens Jr AH, Shnider BI, Gold GL (1961) Toxicity after large doses of noscapine. Cancer Chemother Rep 15:33–34
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Dahlström, B., Mellstrand, T., Löfdahl, C.G. et al. Pharmakokinetic properties of noscapine. Eur J Clin Pharmacol 22, 535–539 (1982). https://doi.org/10.1007/BF00609627
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DOI: https://doi.org/10.1007/BF00609627