Summary
The pharmacokinetics of metronidazole was studied in 20 paediatric patients aged 6 weeks and 4 to 14 years, who had trichomonal vaginitis or an anaerobic bacterial infection. The dosage of metronidazole was about 10 or 20 mg/kg b.i.d. orally. The serum concentrations found in children and the corresponding calculated kinetic parameters were similar to those in adults after intake of an equal, weight-related dose. Metronidazole shows rapid diffusion into the saliva with a concentration ratio of about 1.0. This can provide the basis for an efficient non-invasive method of drug monitoring.
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Amon, I., Amon, K., Scharp, H. et al. Disposition kinetics of metronidazole in children. Eur J Clin Pharmacol 24, 113–119 (1983). https://doi.org/10.1007/BF00613937
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DOI: https://doi.org/10.1007/BF00613937