Abstract
Organochlorine residues (OCR)2 are poorly soluble in water and are transported in the organism bound by the blood components. The distribution among blood fractions (cells/plasma, lipoproteins/rest of plasma proteins) were variable depending on the residue (HCB,p p′-DDE, HCH, Aroclor® 1260, PCP) and on the species (rat, man). Differences were not found betweenin vivo (after oral single dosing) andin vitro (blood incubation) experiments. Results indicated a high affinity of organochlorine residues for lipo-proteins; however, binding to blood carriers was very weak as demonstrated by the rapid release of residues by elution through a reverse phase column. The effects of residue binding to blood components on the distribution kinetics to tissues are discussed.
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Abbreviations
- CM:
-
chylomicrons
- CMC:
-
carboxymethyl cellulose
- DDE:
-
dichlorodiphenyl dichloroethene
- HCB:
-
hexachlorobenzene
- HCH:
-
hexachlorocyclohexane
- HDL:
-
high density lipoproteins
- LDL:
-
low density lipoproteins
- OCR:
-
organochlorine residues
- PCBs:
-
polychlorinated biphenyls
- PCP:
-
pentachiorophenol
- VLDL:
-
very low density lipoproteins
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Gómez-Catalán, J., To-Figueras, J., Rodamilans, M. et al. Transport of organochlorine residues in the rat and human blood. Arch. Environ. Contam. Toxicol. 20, 61–66 (1991). https://doi.org/10.1007/BF01065329
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DOI: https://doi.org/10.1007/BF01065329