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Benzbromarone biotransformation is not related to polymorphic oxidation of sparteine

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References

  1. Clark DWJ (1985) Genetically determined variability in acetylation and oxidation. Therapeutic implications. Drugs 29:342–375

    Google Scholar 

  2. Eichelbaum M (1982) Defective oxidation of drugs: pharmacokinetic and therapeutic implications. Clin Pharmacokin 7:1–22

    Google Scholar 

  3. Eichelbaum M (1983) Genetische Polymorphismen des oxidativen Arzneimittelstoffwechsels. Therapeutische und toxikologische Implikationen. Internist 24:117–127

    Google Scholar 

  4. Eichelbaum M (1988) Genetic polymorphism of sparteine/debrisoquine oxidation. ISI Atlas of Science: Pharmacology (In press)

  5. Eichelbaum M, Spannbrucker N, Steincke B, Dengler HJ (1979) Defective N-oxidation of sparteine in man: a new pharmacogenetic defect. Eur J Clin Pharmacol 16:183–187

    Google Scholar 

  6. Eichelbaum M, Bertilsson L, Säwe J, Zekorn C (1982) Polymorphic oxidation of sparteine and debrisoquine: related pharmacogenetic entities. Clin Pharmacol Ther 31:184–186

    Google Scholar 

  7. Eichelbaum M, Bertilsson L, Säwe J (1983) Antipyrine metabolism in relation to polymorphic oxidations of sparteine and debrisoquine. Br J Clin Pharmacol 15:317–321

    Google Scholar 

  8. Gonzalez FJ, Skoda RC, Kimura S, Umeno M, Zanger UM, Nebert DW, Gelboin HV, Hardwick JP, Meyer UA (1988) Characterization of the common genetic defect in humans deficient in debrisoquine metabolism. Nature 331:442–446

    Google Scholar 

  9. de Vries JX, Walter-Sack I, Ittensohn A (1987) Analysis of benzbromarone in human plasma and urine by high performance liquid chromatography and gas chromatography-mass spectrometry. J Chromatogr 417:420–427

    Google Scholar 

  10. de Vries JX, Walter-Sack I, Löffler W (1987) The biotransformation of benzbromarone in humans. Characterization of a new metabolite by gas chromatography-mass spectrometry. Klin Wochenschr 65, Suppl X:10

    Google Scholar 

  11. Walter-Sack I, de Vries JX, Ittensohn A, Kohlmeier M, Weber E (1988) Benzbromarone disposition and uricosuric action; evidence for hydroxilation instead of debromination to benzarone. Klin Wochenschr 66:160–166

    Google Scholar 

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Walter-Sack, I., Eichelbaum, M., de Vries, J.X. et al. Benzbromarone biotransformation is not related to polymorphic oxidation of sparteine. Klin Wochenschr 66, 1097–1098 (1988). https://doi.org/10.1007/BF01711926

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  • DOI: https://doi.org/10.1007/BF01711926

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