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Treatment of acute toxoplasmosis with intravenous clindamycin

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European Journal of Clinical Microbiology and Infectious Diseases Aims and scope Submit manuscript

Abstract

The interim results are presented of an ongoing large-scale, prospective, randomized study to determine the potential role of clindamycin in the treatment of toxoplasmic encephalitis. Patients were seropositive forToxoplasma gondii antibodies and had clinical signs compatible with toxoplasmic encephalitis. Data was available on 33 patients, 15 of whom received pyrimethamine p.o. / clindamycin i.v. and then p.o., and 18 of whom received pyrimethamine p.o./sulfadiazine p.o. The interim evaluation did not reveal a remarkable difference between the two regimens in the clinical or radiologic response. Adverse reactions to both regimens were common and frequently multiple, there being more adverse gastrointestinal reactions in patients on pyrimethamine/clindamycin and more adverse hematological reactions in those on pyrimethamine/sulfadiazine.

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References

  1. Dannemann BR, Israelski DM, Remington JS Treatment of toxoplasmic encephalitis with intravenous clindamycin. Archives of Internal Medicine 1988, 148: 2477–2482.

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  2. Dannemann BR, Israelski DM, McCutchan JA, Luft BJ, Vildé JL, Antoniskis D, Nussbaum JN, Heseltine PNC, Leedom JM, Remington JS: Treatment of toxoplasmic encephalitis in patients with AIDS: Preliminary report of the California Collaborative Treatment Group randomized trial of pyrimethamine plus sulfonamides versus pyrimethamine plus clindamycin. In: Program and Abstracts of the 28th Interscience Conference on Antimicrobial Agents and Chemotherapy, Los Angeles, 1988, Abstract no. 562.

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Supported by the University of California's University-wide AIDS Research Program.

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Dannemann, B.R., McCutchan, J.A., Israelski, D.M. et al. Treatment of acute toxoplasmosis with intravenous clindamycin. Eur. J. Clin. Microbiol. Infect. Dis. 10, 193–195 (1991). https://doi.org/10.1007/BF01964461

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  • DOI: https://doi.org/10.1007/BF01964461

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