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Excretion of tolbutamide metabolites in young and old subjects

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Summary

Tolbutamide (1 g/70 kg) was administered as a single intravenous dose to 31 healthy, non-smoking, drug-free males between 23 and 87 years old and the total amounts of hydroxy and carboxytolbutamide excreted in 24 h were measured.

There was a significant decrease in the urinary recovery of both metabolites with age.

The reason for these findings is not known at the present time and may be associated with the decrease in creatinine clearance observed in these subjects or other changes in the pharmacokinetics of tolbutamide which are currently being investigated.

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Authors and Affiliations

  1. Department of Pharmaceutics, College of Pharmacy and Pharmacal Sciences, Howard University, 20059, Washington, D.C., USA

    A. K. Miller & J. Adir

  2. Clinical Pharmacology and Gerontology Research Unit, Veterans Affairs Medical Center, 83702, Boise, Idaho, USA

    R. E. Vestal

Authors
  1. A. K. Miller
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  2. J. Adir
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  3. R. E. Vestal
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Miller, A.K., Adir, J. & Vestal, R.E. Excretion of tolbutamide metabolites in young and old subjects. Eur J Clin Pharmacol 38, 523–524 (1990). https://doi.org/10.1007/BF02336696

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  • DOI: https://doi.org/10.1007/BF02336696

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