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A general conceptual model for non-steady state pharmacokinetic/Pharmacodynamic data

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References

  1. N. L. Dayneka, V. Garg, and W. J. Jusko. Comparison of four basic models of indirect pharmacodynamic responses.J. Pharmacokin. Biopharm. 21:457–478 (1993).

    Article  CAS  Google Scholar 

  2. G. Segre. Kinetics of interaction between drugs and biological systems.Il Farmaco 23:906–918 (1968).

    Google Scholar 

  3. D. Verotta and L. B. Sheiner. Semiparametric analysis of non-steady-state pharmacodynamic data.J. Pharmacokin. Biopharm. 19:691–712 (1991).

    Article  CAS  Google Scholar 

  4. R. F. Hoskins.Generalized Functions, Wiley, New York, 1979.

    Google Scholar 

  5. E. B. M. Ekblad and V. Licko. A model eliciting transient responses.Am. J. Physiol. 246:R114-R121 (1984).

    CAS  PubMed  Google Scholar 

  6. P. Z. Marmarelis and V. Z. Marmarelis.Analysis of Physiological Systems. The White-Noise Approach, Plenum Press, New York, 1978.

    Book  Google Scholar 

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Authors and Affiliations

  1. Department of Pharmacy and Pharmaceutical Chemistry, University of California San Francisco, Box 0446, 94143, San Francisco, California

    Davide Verotta & Lewis B. Sheiner

  2. Department of Epidemiology and Biostatistics, University of California San Francisco, San Francisco, California

    Davide Verotta

  3. Department of Laboratory Medicine, School of Medicine, University of California San Francisco, San Francisco, California

    Lewis B. Sheiner

Authors
  1. Davide Verotta
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  2. Lewis B. Sheiner
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Additional information

This work was supported by National Institutes of Health, Education and Welfare Grants GM26691, ACTG UO1 AI 27663.

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Verotta, D., Sheiner, L.B. A general conceptual model for non-steady state pharmacokinetic/Pharmacodynamic data. Journal of Pharmacokinetics and Biopharmaceutics 23, 1–4 (1995). https://doi.org/10.1007/BF02353780

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  • DOI: https://doi.org/10.1007/BF02353780

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