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The sodium bile salt cotransport family SLC10

  • The ABC of Solute Carriers
  • Guest Editor: Matthias A. Hediger
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Abstract

The SLC10 family of sodium/bile salt cotransporters contains over 50 members in animal, plant and bacterial species. In man, two well-characterized members and three orphan transporters are known. The Na+/taurocholate cotransporting polypeptide (NTCP; SLC10A1) and the apical sodium-dependent bile salt transporter (ASBT; SLC10A2) are critical components of the enterohepatic circulation of bile salts. NTCP and ASBT are cotransporters that mediate sodium-dependent, electrogenic uptake of mainly bile salts into hepatocytes (NTCP), biliary epithelial cells, ileal enterocytes and renal proximal tubular cells (ASBT).

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Acknowledgements

The authors were supported by the Swiss National Science Foundation (grant 31-59204.99 to B.H.) and by the NIH (DK 47987 and HL49373 to P.A.D.).

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Authors and Affiliations

  1. Division of Clinical Pharmacology and Toxicology, Department of Medicine, University Hospital, 8091, Zurich, Switzerland

    Bruno Hagenbuch

  2. Wake Forest University School of Medicine, Winston-Salem, NC, USA

    Paul Dawson

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  1. Bruno Hagenbuch
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  2. Paul Dawson
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Correspondence to Bruno Hagenbuch.

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Hagenbuch, B., Dawson, P. The sodium bile salt cotransport family SLC10. Pflugers Arch - Eur J Physiol 447, 566–570 (2004). https://doi.org/10.1007/s00424-003-1130-z

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  • DOI: https://doi.org/10.1007/s00424-003-1130-z

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