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Genotypic and allelic frequencies of SULT1A1 polymorphisms in women receiving adjuvant tamoxifen therapy

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Summary

Human sulfotransferase 1A1 (SULT1A1) is involved in the metabolism of a number of substances including 4-hydroxytamoxifen. It has been shown that patients who are homozygous for the variant SULT1A1 *2/*2 have lower catalytic activity. Previous data has suggested that patients with this particular genotype may be at a greater risk of developing breast cancer or not responding to tamoxifen therapy. To date, there is no data within the Hispanic population on the genotypic and allelic frequencies of the SULT1A1 gene. Two hundred and ninety-six patients were genotyped by either restriction fragment length polymorphism (RFLP) or Pyrosequencing for the SULT1A1 exon 7 polymorphism. The genotypic frequency was 0.47 (*1/*1), 0.40 (*1/*2) and 0.13 (*2/*2) in Caucasians and 0.37 (*1/*1), 0.45 (*1/*2) and 0.18 (*2/*2) in Hispanics. Although Hispanics have a higher genotypic frequency of variant genotypes this difference was not statistically significant (p=0.26). SULT1A1 genotype did not correlate with any prognostic or predictive markers associated with breast cancer. Future evaluations will assess the functional significance of this polymorphism on survival.

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References

  1. Falany C, Wheeler J, Oh T, Falany J, Steroid sulfation by expressed human cytosolic sulfotransferases J Steroid Biochem Mol Biol 1994, 48(4):369–375

    Article  PubMed  CAS  Google Scholar 

  2. Weinshilboum R, Otterness D, Aksoy I, Wood T, Her C, Raftogianis R, Sulfotransferase molecular biology: cDNAs and genes FASEB 1997, 11:3–14

    CAS  Google Scholar 

  3. Raftogianis R, Wood T, Otterness D, Van Loon J, Weinshilboum R, Phenol sulfotransferase pharmacogenetics in humans: association of common SULT1A1 alleles with TS PST phenotype Biochem Biophys Res Commun 1997, 239:298–304

    Article  PubMed  CAS  Google Scholar 

  4. Nowell S, Ambrosone C, Ozawa S, MacLeod S, Mrackova G, Williams S, Plaxco J, Kadlubar F, Lang N, Relationship of phenol sulfotransferase activity (SULT1A1) genotype to sulfotransferase phenotype in platelet cytosol Pharmacogenetics 2000, 10:789–797

    Article  PubMed  CAS  Google Scholar 

  5. Carlini E, Raftogianis R, Wood T, Jin F, Zheng W, Rebbeck T, Weinshilboum R, Sulfation pharmacogenetics: SULT1A1 and SULT1A2 allele frequencies in Caucasian, Chinese and African-American subjects Pharmacogenetics 2001, 11:57–68

    Article  PubMed  CAS  Google Scholar 

  6. Coughtrie M, Gilissen A, Shek B, Strange R, Fryer A, Jones P, Bamber D, Phenol sulphotransferase SULT1A1 polymorphism: molecular diagnosis and allele frequencies in Caucasian and African populations Biochem J 1999, 337:45–49

    Article  PubMed  CAS  Google Scholar 

  7. Seth P, Lunetta K, Bell D, Gray H, Nasser S, Rhei E, Kaelin C, Iglehart D, Marks J, Garber J et al: Phenol sulfotransferases:Hormonal regulation, polymorphism, and age of onset of breast cancer Cancer Res 2000, 60:6859–6863

    PubMed  CAS  Google Scholar 

  8. Zheng W, Xie D, Cerhan J, Sellers T, Wen W, Folsom A, Sulfotransferase 1A1 polymorphism, endogenous estrogen exposure, well-done meat intake, and breast cancer risk Cancer Epidemiol Biomarkers Prev 2001, 10:89–94

    PubMed  Google Scholar 

  9. Nowell S, Sweeney C, Winters M, Stone A, Lang N, Hutchins L, Kadlubar F, Ambrosone C, Association between sulfotransferase 1A1 genotype and survival of breast cancer patients receiving tamoxifen therapy J Natl Cancer Inst 2002, 94(21):1635–1640

    PubMed  CAS  Google Scholar 

  10. Ozawa S, Tang Y-M, Yamzoe Y, Kato R, Lang N, Kadlubar F, Genetic polymorphisms in human liver phenol sulfotransferases involved in the bioactivation of N-hydroxy derivatives of carcinogenic arylamines and heterocyclic amines Chem Biol Interact 1998, 109:237–248

    Article  PubMed  CAS  Google Scholar 

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Acknowledgmets

Supported in part by American Foundation for Pharmaceutical Education Post-Pharm.D. Fellowship, Cancer Center Council Grant, and San Antonio Cancer Institute NCI Cancer Center Support Grant 5P30CA054174.

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Correspondence to J.L. Grabinski.

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Address for offprints and correspondence: Jodi L. Grabinski, University of Texas Health Science Center at San Antonio, 7703 Floyd Curl Drive, MC 6220, San Antonio, TX 78229-3900, USA; Tel.: +1-210-567-8355; Fax: +1-210-567-8328; E-mail: grabinski@uthscsa.edu

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Grabinski, J., Smith, L., Chisholm, G. et al. Genotypic and allelic frequencies of SULT1A1 polymorphisms in women receiving adjuvant tamoxifen therapy. Breast Cancer Res Treat 95, 13–16 (2006). https://doi.org/10.1007/s10549-005-9019-5

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  • DOI: https://doi.org/10.1007/s10549-005-9019-5

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