Focal renal cortical necrosis associated with zomepirac

doi:10.1016/0002-9343(84)90867-2

The American Journal of Medicine

Volume 76, Issue 6, June 1984, Pages 1113-1117

https://doi.org/10.1016/0002-9343(84)90867-2 Get rights and content

Abstract

Anaphylactoid shock, disseminated intravascular coagulation, and anuric renal failure requiring dialysis occurred in a patient receiving zomepirac sodium for toothache. Although renal function showed gradual improvement after seven days of anuria, the recovery was slow and incomplete. Renal biopsy three weeks after the onset of renal failure revealed evidence of focal renal cortical necrosis. Association of zomepirac administration with renal cortical necrosis is not known to have been previously demonstrated. This observation adds another dimension to the previously reported renal complications of nonsteroidal anti-inflammatory agents, especially zomepirac. The proportions of lymphocyte subsets, as defined with monoclonal antibodies, and the proliferative response to mitogens were normal. The patient's lymphocytes showed no proliferative response to zomepirac. Serum complement components and immunoglobulin levels were within normal limits, and radioallergosorbent testing gave negative results. The mechanism of anaphylactoid reaction to zomepirac in this case, therefore, remains unclear.

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¹: From the Department of Medicine, University of California, Irvine, California.

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Case reportFocal renal cortical necrosis associated with zomepirac

Abstract

Reversible nonoliguric acute renal failure associated with zomepirac therapy

Anaphylactic shock, acute renal failure and disseminated intravascular coagulation—suspected complications of zomepirac

JAMA

Zomepirac and renal failure (letter)

Ann Intern Med

An improved turbidometric method for plasma fibrinogen

Am J Med Technol

T cell subpopulations defined with monoclonal antibodies in patients with primary immunodeficiency

Immunol Lett

Lymphocyte transformation to mitogens and antigens

Diagnosis of allergy by in-vitro test for allergen antibodies

Lancet

Rocket immunoelectrophoresis of C4 and C4d. A simple sensitive method for detecting complement activation in plasma

Am J Clin Pathol

Case report
Focal renal cortical necrosis associated with zomepirac