7,8-Benzoflavone stimulates the metabolic activation of aflatoxin B1 to mutagens by human liver

https://doi.org/10.1016/0006-291X(78)90616-2Get rights and content

Abstract

The addition of 7,8-benzoflavone to a monooxygenase system from human liver markedly stimulated the metabolic activation of aflatoxin B1 to mutagens. When 7,8-benzoflavone (5 × 10−5M) was added to this monooxygenase system, the amount of aflatoxin B1 needed for a mutagenic response was decreased by 20- to 40-fold. 7,8-Benzoflavone did not stimulate the metabolic activation of aflatoxin B1 to mutagens when rat liver was used as a source of monooxygenase.

References (21)

  • A.W. Wood et al.

    J. Biol. Chem

    (1976)
  • D.H. Swenson et al.

    Biochem. Biophys. Res. Commun

    (1973)
  • D.H. Swenson et al.

    Biochem. Biophys. Res. Commun

    (1974)
  • F.J. Wiebel et al.

    Arch. Biochem. Biophys

    (1971)
  • S.J. Stohs et al.

    Arch. Biochem. Biophys

    (1976)
  • Y. Imai et al.

    Biochem. Biophys. Res. Commun

    (1966)
  • M.W. Anders

    Arch. Biochem. Biophys

    (1968)
  • J. Kapitulnik et al.

    Clin. Pharmacol. Therap

    (1977)
  • J. McCann et al.
  • B.N. Ames et al.

    Mutation Res

    (1975)
There are more references available in the full text version of this article.

Cited by (0)

View full text
Copyright © 1978 Published by Elsevier Inc.