Biochemical and Biophysical Research Communications
Thyroid hormone suppression of hepatic levels of phenobarbital-inducible P-450b AND P-450e and other neonatal P-450S in hypophysectomized rats
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Activation of brain serotonergic system by repeated intracerebral administration of 5-hydroxytryptophan (5-HTP) decreases the expression and activity of liver cytochrome P450
2016, Biochemical PharmacologyCitation Excerpt :It has been shown that the level of CYP2C11 expression in male rats correlates positively with the serum concentration of GH [20]. On the other hand, thyroid hormones and the investigated interleukins exert negative influence on the activity of the CYP isoforms studied [25,3134]. Therefore we assume that the changes observed in serum hormone concentrations, i.e. a decrease in GH level and an increase in T4 level, negatively influence the expression of the investigated liver CYP isoforms.
Involvement of the paraventricular (PVN) and arcuate (ARC) nuclei of the hypothalamus in the central noradrenergic regulation of liver cytochrome P450
2013, Biochemical PharmacologyCitation Excerpt :It has been found that drugs acting on the central nervous system can influence the activity of cytochrome P450 [52]. Antidepressants enhance monoaminergic (i.e. noradrenergic, dopaminergic or serotonergic) neurotransmission in the brain, which affects the activity of the endocrine system, the latter being known to regulate the expression of cytochrome P450 [43,53–56]. The effect of antidepressant drugs on the expression of numerous CYP isoforms (CYP2B, CYP2C6, CYP2C11, CYP3A1/2 and CYP1A) has been described [40,41,52,57,58].
The role of brain noradrenergic system in the regulation of liver cytochrome P450 expression
2013, Biochemical PharmacologyCitation Excerpt :In contrast to CYP2C11 and CYP3A isoforms, the increased activity of CYP1A may be ascribed to the enhancement of both mRNA and protein expression in the liver. This, in turn, may be due to the observed increase in corticosterone level and the reduced thyroid hormone (T4) concentration in the blood [62,63]. It has been shown that transcriptional activation of rat CYP1A1 gene requires the presence of arylhydrocarbon receptor (AhR) and is positively modulated by physiological concentrations of glucocorticoids via GRE sequences that are conserved within the first intron of CYP1A1 gene in rats, mice and humans [64–66].
Cytochrome P450 is regulated by noradrenergic and serotonergic systems
2011, Pharmacological ResearchCitation Excerpt :Thus the expression of male CYP2A2, CYP2C13, CYP3A2 and 4A2, as well as CYP2B1/2, CYP3A1 and CYP3A18 dominant in males, depends on action of pulsatile GH secretion [11,13–19]. Thyroid hormones (triiodothyronine - T3 and thyroxine - T4) suppress the expression of CYP1A, CYP2A, CYP2B, and CYP3A [14,20–25], while the regulation of CYP2C11 expression seems to be largely independent of these hormones [26,27]. Besides endogenous hormones, the expression of CYP1A/2B/2C/3A is under the suppressive action of cytokines [28].