Studies on the in vivo and in vitro estrogenic activities of methoxychlor and its metabolites. Role of hepatic mono-oxygenase in methoxychlor activation☆
References (34)
- et al.
J. Toxic. Envir. Hlth
(1978) - et al.
Pharmacologist
(1976) - et al.
Med. Biol.
(1975) - et al.
Science, N.Y.
(1971) - et al.
Ann. N.Y. Acad. Sci.
(1971) - et al.
- et al.
Chem. Biol. Interact
(1972) - et al.
Drug. Metab. Dispos.
(1973) Chem. Eng. News
(1975)
Archs Int. Pharmacodyn. Thér.
J. agric. Fd Chem.
CRC Crit. Rev. Toxic.
J. agric. Fd Chem.
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2019, Regulatory Toxicology and PharmacologyCitation Excerpt :The major metabolic pathway for methoxychlor in mice involves sequential demethylation at its p-positions (O-demethylation) yielding mono- and bis-hydroxy methoxychlor derivatives that are preferentially excreted via the feces (Table 3). These demethylated metabolites possess greater endocrine disrupting activity compared to methoxychlor (Bulger et al., 1978; Charles et al., 2000; Maness et al., 1998; Sumida et al., 2001) and are likely to be involved in the reproductive effects of the parent chemical; thus, metabolic activation of methoxychlor is expected through this pathway. Aliphatic dechlorination represents a minor oxidation pathway for methoxychlor that produces metabolites such as bis-hydroxydiphenyl acetic acid, bis-hydroxybenzophenone, and bis-hydroxy-dichloroethylene (Table 3).
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Part of this work was presented at the meeting of the American Society for Pharmacology and Experimental Therapeutics, August 21–25, 1977, Ohio State University, Columbus, OH [Pharmacologist19 (2), abstr. 411].