Effects of flavonoids on the release of reactive oxygen species by stimulated human neutrophils: Multivariate analysis of structure-activity relationships (SAR)
References (57)
- et al.
Effects of flavonoids on immune and inflammatory cell functions.
Biochem Pharmacol
(1992) - et al.
Protein kinase C inhibition by plant flavonoids. Kinetic mechanisms and structure-activity relationships
Biochem Pharmacol
(1989) - et al.
Structure-activity relationships of polymethoxyflavones and other flavonoids as inhibitors of non-enzymic lipid peroxidation
Biochem Pharmacol
(1990) - et al.
Structure-activity studies of flavonoids as inhibitors of hyaluronidase
Biochem Pharmacol
(1990) - et al.
How flavonoids inhibit the generation of luminol-dependent chemiluminescence by activated human neutrophils
Chem Biol Interact
(1990) - et al.
Flavonoids as Superoxide scavengers and antioxidants
Free Radical Biol Med
(1990) - et al.
Scavenger and antioxidant properties of ten synthetic flavones
Free Radical Biol Med
(1992) - et al.
Flavonoids as antioxidants evaluated by in vitro and in situ liver chemiluminescence
Biochem Pharmacol
(1987) - et al.
Antioxidant properties of S 5682
- et al.
Effect of Daflon 500 mg on the factors involved in perivenous inflammation
Phlebology
(1992)
The human N-formylpeptide receptor. Characterization of two cDNA isolates and evidence for a new subfamily of G-protein-coupled receptors
Biochemistry
Pathway of phosphatidyl-inositol (3, 4, 5)-triphosphate synthesis in activated neutrophils
Nature
L'Analyse des Données: II. L'Analyse des Corres-pondances
Exploratory and Multivariate Data Analysis
De la manipulation informatique des formules développées à l'étude des relations structure-activité. Application aux médicaments antiparasitaires
J Pharm Belg
Enhanced arachidonic acid metabolism and human neutrophil migration in asthma
Prostaglandins Leukotrienes Essential Fatty Acids
Phagocytosis induction of chemiluminescence and chemoattractant increased Superoxide anion release from activated human alveolar macrophages in asthma
J Biolum Chemilum
Kaempherol inhibits myosin light chain kinase
Biochem Biophys Res Commun
Differential effects of flavonoids as inhibitors of tyrosine protein kinases and serine/ threonine protein kinases
Biochem Pharmacol
Synthesis and evaluation of hydroxylated flavones and related compounds as potential inhibitors of the protein-tyrosine kinase p56lck
J Natural Prod
Effect of staurospaurine on fMet-Leu-Phe-stimulated human neutrophils: dissociated release of inositol 1,4,5- triphosphate, diacylglycerol and intracellular calcium
Biochim Biophys Acta
Dietary carcinogens and anticarcinogens. Oxygen radicals and degenerative diseases
Science
Readers' replies: Science
Readers' replies: Science
Oxygen free radicals linked to many diseases
Research News report on NHLBI symposium entitled “Oxygen Free Radicals”
Science
Prooxidant states and tumor promotion
Science
Inhibition of mitochondrial respiration and production of toxic oxygen radicals by flavonoids. A structure-activity study
Biochem Pharmacol
Cited by (103)
Antagonism of human formyl peptide receptor 1 with natural compounds and their synthetic derivatives
2016, International ImmunopharmacologyCitation Excerpt :However, ROS scavenging activity of flavonoids and isoflavones may also contribute to the observed effects [71,72], especially in tests of fMLF-induced ROS production (see Fig. 1). For example, luteolin and apigenin apparently inhibited O2− production in fMLF-stimulated neutrophils [73–75], but these flavonoids also inhibited neutrophil O2− generation induced by phorbol-12-myristate-13-acetate (PMA) and tyrosine phosphorylation of proteins in fMLF-treated human neutrophils [76,77], suggesting ROS scavenging activity rather than FPR1 antagonism. Several synthetic isoflavone derivatives have been identified as small-molecule competitive FPR1 antagonists [19,78,79].
UHPLC profiling and effects on LPS-stimulated J774A.1 macrophages of flavonoids from bergamot (Citrus bergamia) juice, an underestimated waste product with high anti-inflammatory potential
2014, Journal of Functional FoodsCitation Excerpt :Our results are in accordance with a previous study regarding the protective effect of a bergamot extract on keratinocytes in inflammatory conditions. In particular, it has been reported that the main flavonoids, such as neoeriocitrin, naringin and neohesperidin, occurring in bergamot extract, were protective against inflammatory injuries in human keratinocytes by reducing pro-inflammatory mediators as NO and iNOS (Limasset et al., 1993). Our data provided evidences that C. bergamia juice constituents could exert beneficial effects as antioxidants and inhibitors of inflammation process in LPS-stimulated J774A.1 macrophages.
Naringenin suppresses the production of thymic stromal lymphopoietin through the blockade of RIP2 and caspase-1 signal cascade in mast cells
2011, European Journal of PharmacologyCitation Excerpt :NF-κB activated by caspase-1 mediates the induction of TSLP gene expression in airway epithelial cells (Lee and Ziegler, 2007). The abundant flavonoid aglycone, naringenin (Fig. 1), which is responsible for the bitter taste in grapefruit, has various effects such as anti-atherogenic, anti-oxidant and anti-inflammatory effects (Hämäläinen et al., 2007; Limasset et al., 1993; Mulvihill and Huff, 2010; Shulman et al., 2011). However, the effect of naringenin on the production of TSLP has not yet been clarified.
Leucine enhances aerosol performance of Naringin dry powder and its activity on cystic fibrosis airway epithelial cells
2011, International Journal of PharmaceuticsCitation Excerpt :However, these drugs have limited beneficial effects in presence of considerable side effects. Among natural polyphenols, flavonoids such as Naringin (N) obtained from grapefruits showed anti-inflammatory, antioxidant and anticarcinogenic effects (Limasset et al., 1993). In addition, flavonoids may act as CFTR direct activators, stimulating transepithelial chloride transport (Azbell et al., 2010; Pyle et al., 2009; Springsteel et al., 2003; Virgin et al., 2010; Wegrzyn et al., 2010).
Decreased activity of neutrophils in the presence of diferuloylmethane (curcumin) involves protein kinase C inhibition
2009, European Journal of Pharmacology