Research paperExpression of functional cytochrome P4501A1 in human embryonic hepatic tissues during organogenesis
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2022, Advances in PharmacologyCitation Excerpt :In adults, CYP1A1 exists largely extrahepatically, such as in the lung and placenta, and is known to be induced by cigarette smoking and/or other inducers mediated through an aryl hydrocarbon receptor (Zevin & Benowitz, 1999). However, the mRNA of CYP1A1 has been identified in fetal livers aged as early as 45 days of gestation and its expression was higher in older gestational ages (Omiecinski, Redlich, & Costa, 1990; Yang, Namkung, & Juchau, 1995). Interestingly, its immunoreactive expression in fetal livers showed no apparent zonal distribution (Murray et al., 1992).
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