Block of deltamethrin-modified sodium current in cultured mouse neuroblastoma cells: local anesthetics as potential antidotes
Reference (38)
- et al.
The action of mephenesin and other agents on the effects produced by two neurotoxic pyrethroids in the intact and spinal rat
Neuropharmacology
(1983) - et al.
Protection against pyrethroid toxicity in rats with mephenesin
Toxicol. Appl. Pharmacol.
(1981) Local anesthetic block of sodium channels in normal and pronase-treated squid giant axons
J. Biophys.
(1978)- et al.
Deltamethrin: a neurophysiological study of the sites of action
Pestic. Biochem. Physiol.
(1987) - et al.
Pyrethroid toxicology in the frog
Pestic. Biochem. Physiol.
(1983) - et al.
Regional changes in brain glucose utilization in rats given a pyrethroid insecticide
Brain Research
(1980) - et al.
Pyrethroid toxicology: protective effects of diazepam and phenobarbital in the mouse and the cockroach
Toxicol. Appl. Pharmacol.
(1982) - et al.
The suction pipette method for internal perfusion and voltage clamp of small excitable cells
J. Neurosci. Methods
(1980) - et al.
Effects of pyrethroids on neurotransmitter-operated ion channels in cultured mouse neuroblastoma cells
Pestic. Biochem. Physiol.
(1989) - et al.
Increase of sodium current after pyrethroid insecticides in mouse neuroblastoma cells
Brain Research
(1987)
A pharmacological study of pyrethroid neurotoxicity in mice
Pestic. Biochem. Physiol.
(1982)
Interaction of pyrethroids with mammalian spinal neurons
Pestic. Biochem. Physiol.
(1986)
The action of pyrethroids on sodium channels in myelinated nerve fibres and spinal ganglion cells of the frog
Brain Research
(1989)
Na channel activation gate modulates slow recovery from use-dependent block by local anesthetics in squid giant axons
Biophys. J.
(1985)
Modification of single sodium channels by the insecticide tetramethrin
Brain Research
(1983)
Neurotransmitter synthesis by neuroblastoma clones
Molecular properties of sodium channels in excitable membranes
Stabilization of sodium channel states by deltamethrin in mouse neuroblastoma cells
J. Physiol. (Lond.)
(1986)
Effet antagoniste du phenprobamate et du carbamate de méphénésine sur l'intoxicationàla deltaméthrine
J. Toxicol. Clin. Exp.
(1987)
Cited by (13)
Neurophysiological Effects of Insecticides
2010, Hayes' Handbook of Pesticide ToxicologyNeurophysiological Effects of Insecticides
2010, Hayes' Handbook of Pesticide Toxicology, Third Edition: Volume 1The effects of combined exposure to the pyrethroids deltamethrin and S-bioallethrin on hippocampal inhibition and skeletal muscle hyperexcitability in rats
2006, Toxicology and Applied PharmacologyA reassessment of the neurotoxicity of pyrethroid insecticides
2006, Pharmacology and TherapeuticsCitation Excerpt :An ideal therapeutic agent would antagonize the abnormal, pyrethroid-evoked sodium current but leave the normal one unchanged. In a survey of the relative ability of a range of drugs to antagonize the deltamethrin-evoked and normal sodium currents in neuroblastoma cells (Oortgiesen et al., 1990), it was found that tetracaine and lidocaine were particularly effective. Lidocaine was also effective at antagonizing deltamethrin effects in intact rat hippocampus (Joy et al., 1990), and procainamide modestly effective against motor signs (Bradbury et al., 1983), but local anesthetics are not practical for systemic therapy because of their cardiotoxicity.
An 80-year-old woman with alzheimer disease and accidental poisoning with pyrethroid pesticide successfully treated with intravenous lipid emulsion
2021, American Journal of Case Reports
Copyright © 1990 Published by Elsevier B.V.