Studies on human serum paraoxonase/arylesterase
References (15)
- et al.
Purification and cloning of human serum paraoxonase/arylesterase
FASEB J.
(1991) - et al.
Characterization of cDNA clones encoding rabbit and human serum paraoxonase: the mature protein retains its signal sequence
Biochemistry
(1991) - et al.
The human serum paraoxonase/arylesterase polymorphism
Am. J. Hum. Genet.
(1983) - et al.
Distinction between ‘A’-esterases and arylesterases
Biochem. J.
(1987) Human serum paraoxonase/arylesterase
- et al.
Purification of human serum paraoxonase/arylesterase, evidence for one esterase catalyzing both activities
Drug Metab. Dispos.
(1991) - et al.
Characteristics of the genetically determined allozymic forms of human serum paraoxonase/arylesterase
Drug Metab. Dispos.
(1991)
Cited by (104)
Enhancement in the production of recombinant human paraoxonase 1 in Escherichia coli: A comprehensive approach of cellular engineering and optimization of protein folding process in vitro
2022, International Journal of Biological MacromoleculesCitation Excerpt :His 134 helps to increase the basicity of His 115 [7]. PON1 plays an important role in the protection against organophosphates such as parathion, chlorpyrifos [9] and nerve agents such as sarin and nerve V [10]. Along with this, PON1 also plays other roles in humans, such as prevention of atherosclerosis, LDL oxidation and other cardiovascular diseases [11].
Biotransformation of warfare nerve agents
2020, Handbook of Toxicology of Chemical Warfare AgentsBiotransformation of Warfare Nerve Agents
2015, Handbook of Toxicology of Chemical Warfare Agents: Second EditionQ192R polymorphism of paraoxonase 1 gene associated with insulin resistance in Mexican children
2015, Archives of Medical ResearchSerum paraoxonase activity is associated with variants in the PON gene cluster and risk of Alzheimer disease
2012, Neurobiology of AgingCitation Excerpt :PON1 and PON3 are found in serum whereas PON2 is primarily an intracellular enzyme (Stoltz et al., 2009). In vitro, paraoxonase activity in serum can be measured using colorimetric assays (Browne et al., 2007; Furlong et al., 1989; Nozawa et al., 1980) utilizing a variety of indicator substrates (La Du et al., 1993; Lockridge et al., 1980; Smolen et al., 1991) including thiobutyl butyrolactone (TBBL) and phenyl acetate (PA). The PA assay, which measures an arylesterase activity of paraoxonase, is a widely used assay but may not represent a native physiological activity (Khersonsky et al., 2006).