Short communicationFailure of ketamine to interact with opiate receptors
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Cited by (41)
Beating pain with psychedelics: Matter over mind?
2022, Neuroscience and Biobehavioral ReviewsCitation Excerpt :Ketamine has analgesic effects – as shown in a number of studies a ketamine has been used to treat chronic pain (Carme et al., 1992; Orhurhu et al., 2019; Yang et al., 2020a,b; Kamp et al., 2019) across a number of chronic pain conditions including neuropathic pain (Maher et al., 2017; Backonja et al., 1994; Kim et al., 2013), complex regional syndrome (Azari et al., 2012), but there are risks to the use of the drug (Niesters et al., 2014). Ketamine may induce analgesia via endogenous opioid systems since the action is inhibited by the opioid antagonist naloxone (Smith et al., 1987; Finck and Ngai, 1982) although some have disputed this (Fratta et al., 1980). Taken together, ketamine provides a window into the potential utility of psychedelics for chronic pain.
Mechanisms of ketamine and its metabolites as antidepressants
2022, Biochemical PharmacologyCitation Excerpt :The strength of interaction between ketamine and its metabolites with opioid receptors are stereoselective and vary depending on the receptor [207]. The possibility that ketamine may be directly interacting with opioid receptors began as a controversial topic, with some studies observing or failing to observe displacement of opioid receptor ligands by ketamine [63,64,177]. A growing body of evidence has since supported an interaction between ketamine and opioid receptors.
The mesenterially perfused rat small intestine: A versatile approach for pharmacological testings
2014, Annals of AnatomyCitation Excerpt :The mechanism of action of ketamine is not fully understood. A connection between ketamine and opioid receptors was suspected, but could not be demonstrated in earlier studies (Fratta et al., 1980). More recent studies describe ketamine's main mechanism of action as an antagonistic effect at the voltage dependent NMDA receptors, inducing a “dissociative state” in patients (Adams, 1998; Bergman, 1999).
8 The NMDA-antagonist ketamine for prevention and treatment of acute and chronic post-operative pain
1995, Bailliere's Clinical Anaesthesiology