Central α2-adrenoceptors are highly stereoselective for dexmedetomidine, the dextro enantiomer of medetomidine
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2020, Neurobiology of DiseaseInvestigation of the complexation between cyclodextrins and medetomidine enantiomers by capillary electrophoresis, NMR spectroscopy and molecular modeling
2018, Journal of Chromatography ACitation Excerpt :Medetomidine (4-[1-(2,3- dimethylphenyl)ethyl]-1H-imidazole) is an α2-adrenoreceptor agonist, which is used as an analgesic and anesthetic drug in veterinary medicine [28]. The pharmacological activity has been attributed mainly to the dextrorotary (S)-enantiomer dexmedetomidine [29], which has been developed for human use as a sedative in anesthesia management in surgery and in intensive care medicine [30]. In the process of the development of a CE-based assay for the determination of the stereochemical purity of dexmedetomidine using CDs as chiral selectors [31], different enantiomer migration orders depending on the CD were observed.
Lateral habenular norepinephrine contributes to states of arousal and anxiety in male rats
2018, Behavioural Brain ResearchEffect of dexmedetomidine and xylazine followed by MK-467 on gastrointestinal microperfusion in anaesthetized horses
2018, Veterinary Anaesthesia and Analgesia
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