[3H]Monoamine releasing and uptake inhibition properties of 3,4-methylenedioxymethamphetaimne and p-chloroamphetamine analogues
References (54)
- et al.
MDMA-induced neurotoxicity: Parameters of degeneration and recovery of brain serotonin neurons
Pharmacol. Biochem. Behav.
(1988) - et al.
Long-term effects of 4-chloro-amphetamine on brain 5-hydroxyindole metabolism in rats
Neuropharmacology
(1974) - et al.
Comparison of the effects of 6-chloro-2-aminotetralin and of ORG 6582, a related chloroamphetamine analog, on brain serotonin metabolism in rats
Biochem. Pharmacol.
(1977) - et al.
Effects of the enantiomers of MDA, MDMA and related analogues on [3H]serotonin and [3H]dopamine release from superfused rat brain slices
European J. Pharmacol.
(1986) - et al.
Behavioral, biochemical and neurotoxicological actions of the α-ethyl homologue of p-chloroamphetamine (PCA)
European J. Pharmacol.
(1990) - et al.
Neurotoxic effects of the alpha-ethyl homologue of MDMA following subacute administration
Pharmacol. Biochem. Behav.
(1989) - et al.
Evidence for dual serotonergic projections to neocortex: Axons from the dorsal and median raphe nuclei are differentially vulnerable to the neurotoxin p-chloroamphetamine (PCA)
Exp. Neurol.
(1988) - et al.
Prepulse inhibition of the acoustic response is disrupted by N-ethyl-3,4-methyl-enedioxyamphetamine (MDEA) in the rat
European J. Pharmacol.
(1989) - et al.
The hepatic microsomal metabolism of β-3,4-methylenedioxyamphetamine (MDA)
Life Sci.
(1974) - et al.
Effects of raccinic, (S)- and (R)-methylenedioxyamphetamine on synaptosomal uptake and release of Iritiated norepinephrine
Biochem. Pharmacol.
(1978)
Metabolism of β-3,4-methylenedioxyamphetamine in the rat
Biochem. Pharmacol.
(1978)
5-Iodo-2-aminoindan: A non-neurotoxic analogue of p-doamphetamine
Pharmacol. Biochem. Behav.
(1991)
Interactions between reserpine and various compounds on the accumulation of [14C]5-hydroxytryptamine and [3H]noradrenaline in homogenates from rat hypothalamus
Biochem. Pharmacol.
(1979)
Acute administration of methylenedioxymethainphetamine: comparison with the neurochemical effects of its N-desmethyl and N-ethyl analogs
European J. Pharmacol.
(1987)
In vitro and in vivo neurochemical effects of methylenedioxymethamphetamine on stiatal monoaminergic systems in the rat brain
Biochem. Pharmacol.
(1987)
Depression of rat brain tryptophan hydroxylase activity following the acute administration of methylenedioxymethamphetamine
Biochem. Pharmacol.
(1987)
Stereochemica 1 effects of 3,4-methylenedioxymethamphetamine (MDMA) and related amphetamine derivatives on inhibition of uptake of [3H]monoamines into synaptosomes from different regions of rat brain
Biochem. Pharmacol
(1987)
A comparison of the neurotoxic potential of methylenedioxyam-phetamine (MDA) and its N-methylated and N-ethylated derivatives
European J. Pharmacol.
(1987)
The effects of 3,4-methylenedioxymethamphetamine (MDMA) and 3,4-methylenedioxyamphetamine (MDA) on monoaminergic systems in the rat brain
European J. Pharmacol.
(1986)
Release of [3H]5-hydroxytryptamine by amiflamine and related phenylalkyi-amines from rat occipital cortex slices
Naunyn-Schmiedeb. Arch. Pharmacol.
(1989)
Inhibition of 5-hydroxytryptaniine accumulation and deamination by substituted phenylalkylamines in hypothalamic synaptosomes from normal and reserpine-pretreated rats
Naunyn-Schmiedeb. Arch. Pharmacol.
(1987)
3,4-Methylenedioxymethamphetamine and 3,4-methylenedioxyamphetamine destroy serotonin terminals in rat brain: Quantification of neurodegeneration by measurement of [3H]paroxetine-labeled serotonin uptake sites
J. Pharmacol. Exp.Ther.
(1987)
Serotonin release contributes to the locomotor stimulant effects of 3,4-methylene-dioxyrnethainphetamine (MDMA) in rats
J. Pharmacol. Exp. Ther.
(1990)
Stereochemical differences in the metabolism of 3,4-methylenedioxymethamphetamine in vivo and in vitro: A pharmacokinetic analysis
Drug Metab. Disp.
(1990)
Biochemical and histological evidence that methylenedioxymethamphetamine (MDMA) is toxic to neurons in the rat brain
J. Pharmacol. Exp. Ther.
(1987)
6-Chloro-2-aminotetralin, a rigid confornialional analog of 4-chloroamphetamine: Pharmacological properties of it and related compounds in rats
Arch., Int. Pharmacodyn.
(1974)
p-Iodoamphetamine as a serotonin depletor in rats
J. Pharmacol. Exp. Ther.
(1980)
Cited by (90)
Pharmacological profile of mephedrone analogs and related new psychoactive substances
2018, NeuropharmacologyUse of in vitro models in drug development and issue resolution
2018, Advanced Issue Resolution in Safety PharmacologyEmerging toxicity of 5,6-methylenedioxy-2-aminoindane (MDAI): Pharmacokinetics, behaviour, thermoregulation and LD50 in rats
2016, Progress in Neuro-Psychopharmacology and Biological PsychiatryDesigner psychostimulants: Pharmacology and differences
2014, NeuropharmacologyPharmacological profiles of aminoindanes, piperazines, and pipradrol derivatives
2014, Biochemical PharmacologyCitation Excerpt :Similar inhibitory effects of 5-IAI and MDAI on human monoamine transporters have recently been shown [7], but no comparable data on monoamine release are available. In contrast to the human transporter studies, both MDAI and 5-IAI were relatively more potent SERT and DAT vs. NET inhibitors in rat brain synaptosomes [33]. Similar to our data, MDAI released 5-HT, but not DA, and 5-IAI released both 5-HT and DA from rat brain synaptosomes [33].
Copyright © 1991 Published by Elsevier B.V.