Influence of hepatic microsomal mixed function oxidation reactions on cellular metabolic control☆
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Cited by (107)
Roles of cytochrome P450 enzymes in pharmacology and toxicology: Past, present, and future
2022, Advances in PharmacologyCitation Excerpt :Although the mitochondrial P450s clearly have important roles in the metabolism of steroids and vitamins (Table 1) (Guengerich, 2015), in some cases they can also be involved in the metabolism of drugs (Zhang et al., 2012) and other chemicals. In mammalian liver the ratio of total P450 to POR has long been known to be 10–20:1 (Estabrook, Franklin, Cohen, Shigamatzu, & Hildebrandt, 1971). The concentrations of several P450s in human liver have been estimated using immunochemical (Shimada, Yamazaki, Mimura, Inui, & Guengerich, 1994) and, more recently, mass spectrometry proteomic approaches (Achour, Al Feteisi, Lanucara, Rostami-Hodjegan, & Barber, 2017).
Molecular mechanism of metabolic NAD(P)H-dependent electron-transfer systems: The role of redox cofactors
2019, Biochimica et Biophysica Acta - BioenergeticsCitation Excerpt :Thus, an possible X-shaped contact model for the cyt P450 reductase-cyt P450 complex is shown in Fig. 9. Taken together, the concentration of cyt P450 reductase in the ER membranes has been estimated to be 1/10–1/40 of the total cyt P450s [166,167], indicating that a single cyt P450 reductase must interact with 50 microsomal cyt P450s. It is likely that the interactions between cyt P450 reductase and cyt P450s are relatively weak, including interactions between the soluble domains and their anchors.
Plasticity of specialized metabolism as mediated by dynamic metabolons
2015, Trends in Plant ScienceNADPH P450 oxidoreductase: Structure, function, and pathology of diseases
2013, Pharmacology and TherapeuticsCitation Excerpt :In the lipid reconstituted in vitro systems P450 proteins form a complex with POR with an apparent Km of 0.2 μM (Davydov et al., 1996; Guengerich & Johnson, 1997; Backes & Kelley, 2003). P450 content in most tissues is about 5–10 fold higher than POR (Estabrook et al., 1971; Shephard et al., 1983; Shephard et al., 1992). Chemical agents have been shown to alter the POR:P450 ratio and phenobarbital treatment has been reported to change the POR:P450 ratio to 1:30.
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Supported in part by USPH Research Grant 5 P11 GM 16488