In vitro studies on the action of CS-045, a new antidiabetic agent☆
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2015, Bioorganic and Medicinal ChemistryCitation Excerpt :Thiazolidine-2,4-dione (TZD) is an important heterocyclic ring system that exhibit a range of pharmacological activities, but not limited to, including anti-hyperglycemic,1 anti-cancer,2 anti-arthritic,3 anti-inflammatory4 and anti-microbial,5 etc. Among them, anti-hyperglycemic is the widely studied effect of TZD derivatives that has also been extended to the development of clinically used ‘glitazone’ drugs such as rosiglitazone,6 pioglitazone,7 lobeglitazone8 and troglitazone,9 etc. The first ever pharmacological evaluation, that is, anti-TB activity, of any TZD derivative was reported by an Italian scientist ‘Vistentini’ in 195410 and following this, in the same year, Marshall and Vallance11 reported the anti-convulsing activity of other TZD derivatives.
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