The effects of chronic ingestion of spironolactone on serum thyrotropin and thyroid hormones in the male rat☆
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Endocrine System
2013, Haschek and Rousseaux's Handbook of Toxicologic PathologyEndocrine System
2013, Haschek and Rousseaux's Handbook of Toxicologic Pathology, Third Edition: Volume 1-3N-vinylpyrrolidone dimer, a novel formulation excipient, causes hepatic and thyroid hypertrophy through the induction of hepatic microsomal enzymes in rats
2012, Toxicology LettersCitation Excerpt :Hence, chronic dosing with drugs, such as PB, simvastatin, rifampicin or spironolactone, produces thyroid hyperplasia and neoplasia in rodents (McClain et al., 1989; Semler et al., 1989; Smith et al., 1991; Wu and Farrelly, 2006). Importantly, there is no elevation in TSH or increased risk of thyroid neoplasia in humans chronically treated with these drugs (Clemmesen et al., 1974; Olsen et al., 1989; Semler et al., 1989). Likewise, when these drugs are evaluated at high doses in toxicology studies using nonrodent species, such as dogs or monkeys, induction of DMEs leading to changes in T3, T4 or TSH resulting in thyroid gland hyperplasia is typically not detected.
Subacute toxicity of p,p′-DDT on rat thyroid: Hormonal and histopathological changes
2010, Environmental Toxicology and PharmacologyCitation Excerpt :Alteration of the enzymes involved in the thyroid hormone metabolism has been described as a mechanism for reducing the amount of available hormone (Curran and De Groot, 1991). Yet, it has been suggested that hepatic microsomal enzyme inducers, like phenobarbital and DDT enhanced the glucuronidation and biliary excretion of thyroid hormones via induction of the hepatic T4 uridinediphospho-glucuronyltransferase (UDP-GT) (Bastomsky, 1974; McClain et al., 1989; Semler et al., 1989). The possibility of changes in T4–T3 conversion in the thyroid gland and peripheral tissues could also be envisaged as a mechanism to explain the alteration of thyroid hormones concentrations.
The acceleration of amygdala kindling epileptogenesis by chronic low-dose corticosterone involves both mineralocorticoid and glucocorticoid receptors
2007, PsychoneuroendocrinologyCitation Excerpt :Doses of antagonists, dissolved in propylene glycol (vehicle), and the route and timings of injections were chosen based on recent functional studies and binding assays demonstrating selective antagonism of MR and GR receptors (Herman and Spencer, 1998; McCullers et al., 2002; Koenig and Olive, 2004). Further, 50 mg/kg spironolactone has been shown to block MR effectively (Herman and Spencer, 1998) without toxicity (Semler et al., 1989), and the chosen dose of mifepristone can protect CA1 hippocampal neurons after brain injury (McCullers et al., 2002). Rats received antagonist or vehicle (CS (n=9) and water groups (n=9)) injections twice daily (∼09:00 and 17:00 h) over the same period as CS administration.
Polybrominated diphenyl ether (PBDE)-induced alterations in vitamin A and thyroid hormone concentrations in the rat during lactation and early postnatal development
2006, Toxicology and Applied Pharmacology
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This work was presented in part at the annual meeting of the Society of Toxicology in Dallas, Texas, February 1988.