Elsevier

Virology

Volume 30, Issue 4, December 1966, Pages 731-737
Virology

Functional significance of sialidase during influenza virus multiplication

https://doi.org/10.1016/0042-6822(66)90178-4Get rights and content

Abstract

Highly specific and active antiserum against fowl plague virus sialidase has been prepared. This antiserum is devoid of demonstrable hemagglutinating inhibiting and virus neutralizing capacity. It strongly inhibits the sialidase of fowl plague virus, and when it is added to monolayers infected with fowl plague virus, no hemagglutinin, no infective virus, nor any sialidase activity is released from the infected cells. These cells synthesized the normal amount of complement-fixing antigen and approximately one-third of the normal number of infective units. Thus, the results strongly suggest that one of the most important functions of sialidase may be for the release of virion from infected cells.

References (18)

There are more references available in the full text version of this article.

Cited by (123)

  • Advances in the development of entry inhibitors for sialic-acid-targeting viruses

    2021, Drug Discovery Today
    Citation Excerpt :

    This consequently causes an influx of H+ ions via the M2 ion channel, which in turn leads to the release of the viral ribonucleoprotein into the cytoplasm [28,29]. After replication of the virus has taken place in the host cell, neuraminidase (also known as sialidase) is responsible for the enzymatic cleavage of sialic acid residues, with which it facilitates the release of virions into the extracellular milieu [30]. Prevention of influenza virus infections primarily relies on vaccination.

  • Development of a surveillance scheme for equine influenza in the UK and characterisation of viruses isolated in Europe, Dubai and the USA from 2010-2012

    2014, Veterinary Microbiology
    Citation Excerpt :

    HA mediates virus entry, by binding to sialic acid receptors on the host cell surface and mediating fusion of viral and host membranes (Skehel and Wiley, 2000). NA is involved in virus release from infected cells by cleaving sialic acid, it may also play a role in virus entry by allowing the virus to penetrate the mucus layer of the respiratory tract (Seto and Rott, 1966; Matrosovich et al., 2004). Two subtypes of influenza are known to have infected horses, H3N8 and H7N7.

View all citing articles on Scopus

Supported in part by a fellowship grant to JTS from United Health Foundations Inc., New York, by contract ONR NONR 3723(00) between the Office of Naval Research, Department of the Navy, and California State College at Los Angeles, and by “Deutsche Forschungsgemeinschaft.”

2

Permanent address: Department of Microbiology, California State College, Los Angeles, California, 90032.

View full text