Functional significance of sialidase during influenza virus multiplication☆
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Advances in the development of entry inhibitors for sialic-acid-targeting viruses
2021, Drug Discovery TodayCitation Excerpt :This consequently causes an influx of H+ ions via the M2 ion channel, which in turn leads to the release of the viral ribonucleoprotein into the cytoplasm [28,29]. After replication of the virus has taken place in the host cell, neuraminidase (also known as sialidase) is responsible for the enzymatic cleavage of sialic acid residues, with which it facilitates the release of virions into the extracellular milieu [30]. Prevention of influenza virus infections primarily relies on vaccination.
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2016, Current Opinion in ImmunologyDevelopment of a surveillance scheme for equine influenza in the UK and characterisation of viruses isolated in Europe, Dubai and the USA from 2010-2012
2014, Veterinary MicrobiologyCitation Excerpt :HA mediates virus entry, by binding to sialic acid receptors on the host cell surface and mediating fusion of viral and host membranes (Skehel and Wiley, 2000). NA is involved in virus release from infected cells by cleaving sialic acid, it may also play a role in virus entry by allowing the virus to penetrate the mucus layer of the respiratory tract (Seto and Rott, 1966; Matrosovich et al., 2004). Two subtypes of influenza are known to have infected horses, H3N8 and H7N7.
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Supported in part by a fellowship grant to JTS from United Health Foundations Inc., New York, by contract ONR NONR 3723(00) between the Office of Naval Research, Department of the Navy, and California State College at Los Angeles, and by “Deutsche Forschungsgemeinschaft.”
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Permanent address: Department of Microbiology, California State College, Los Angeles, California, 90032.