An analysis of cocaine effects on locomotor activities and heart rate in four inbred mouse strains
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The effects of cocaine on heart rate and electrocardiogram in zebrafish (Danio rerio)
2015, Comparative Biochemistry and Physiology Part - C: Toxicology and PharmacologyCitation Excerpt :In contrast, very few studies have examined the correspondence of acute cardiovascular sensitivity to cocaine and reward-based learning in rodents. One study compared acute locomotor and cardiovascular responses to cocaine, suggesting that the two roughly correspond (Ruth et al., 1988). The prediction would be then that a different cardiovascular response to cocaine might reflect reward-based learning and thus perhaps indicate vulnerability to addiction.
LC/MS/MS evaluation of cocaine and its metabolites in different brain areas, peripheral organs and plasma in cocaine self-administering rats
2012, Pharmacological ReportsCitation Excerpt :For instance, in male Sprague-Dawley rats found that after acute cocaine (10–20 mg/kg, ip) treatment, the medial PFC drug concentration was nearly 1.3- and 2-fold higher than in the STR or limbic areas (the NAC, olfactory tubercle and pyriform cortex), respectively [6]. Comparison between brain samples indicated the statistically significant differences (8–12%) between STR vs. NAC after 10 mg/kg ip [19], however, such regional concentration difference was not always observed after ip administration of cocaine by other authors [8, 21, 39]. The other important observation is a marked difference between brain, peripheral organs and serum cocaine concentration.
Age and genetic strain differences in response to chronic methylphenidate administration
2011, Behavioural Brain ResearchCitation Excerpt :Although the etiology of ADHD is not yet fully understood, there seems to be a strong underlying genetic component, which has been supported by familial, adoptive, and twin studies [22,23]. Furthermore, strain differences in the acute and chronic response to cocaine in the development of behavioral sensitization in mice have been reported [24–26]. However, rat strain comparisons of the acute and chronic effects of MPD are limited.
Comparison of toluene-induced locomotor activity in four mouse strains
2010, Pharmacology Biochemistry and BehaviorRegional differences in the effects of withdrawal from repeated cocaine upon Homer and glutamate receptor expression: A two-species comparison
2007, Brain ResearchCitation Excerpt :Whether or not the species differences in cocaine's effects upon glutamate receptor expression reflect differences in the cocaine responsiveness of the mesocorticolimbic glutamate system between mouse and rat or rather, relate to the particular mouse and rat strains employed cannot be discerned from the present report. However, in support of the latter possibility, significant strain differences exist in the behavioral effects of cocaine in both rats (Glowa et al., 1994; Kosten et al., 1997) and mice (Orsini et al., 2005; Ruth et al., 1988; Wiener and Reith, 1990; Womer et al., 1994), with the majority of studies demonstrating lower cocaine behavioral responsiveness in the C57BL/6J strain. In the present study, cocaine-induced changes in CC-Homer expression were coincident with alterations in the mGluR1a, but not the mGluR5, subtype of Group1 mGluR in all brain areas investigated.
Serotonin and psychostimulant addiction: Focus on 5-HT<inf>1A</inf>-receptors
2007, Progress in Neurobiology