Recent studies of nicotine metabolism in humans☆
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Cited by (94)
Peripheral DISC1 protein levels as a trait marker for schizophrenia and modulating effects of nicotine
2014, Behavioural Brain ResearchCitation Excerpt :After isolation the cell pellets were flash-frozen and stored at −80 °C until further processing. Cotinine is the main metabolite of nicotine [43]. Due to its longer half-life of 20 h, in contrast to nicotine which has a much shorter half-life of about 20 min, it is widely used as a biomarker of nicotine exposure.
Simple, fast and sensitive LC-MS/MS analysis for the simultaneous quantification of nicotine and 10 of its major metabolites
2014, Journal of Chromatography B: Analytical Technologies in the Biomedical and Life SciencesCitation Excerpt :However, the new method revealed an underestimation by 50% for NorCot and an overestimation for OH-Cot-Gluc by 40% as compared to the previous method. Nicotine is metabolized primarily by the liver enzymes CYP2A6, UDP-glyucuronosyltransferase (UGT) and flavin containing monooxygenase (FMO) [9,45,46]. Urinary nicotine and metabolite concentrations have been widely used to determine nicotine equivalents as an estimate of the nicotine dose that is taken up by smoking or use of other tobacco and nicotine products [37,28,32,47].
Estimating tar and nicotine exposure: Human smoking versus machine generated smoke yields
2010, Regulatory Toxicology and PharmacologyApplication of nicotine enantiomers, derivatives and analogues in therapy of neurodegenerative disorders
2007, European Journal of Pharmacology
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Supported in part by U.S. Public Health Service Grants DAO2277, CA32389 and DAO1696. Studies were carried out in part in the General Clinical Research Center (RR-00083) with support of the Division of Research Resources, National Institutes of Health.