Induction of hepatic P-glycoprotein enhances biliary excretion of vincristine in rats
References (29)
- et al.
Mechanism of multidrug resistance
Biochim Biophys Acta
(1988) - et al.
Multidrug resistance
Adv Cancer Res
(1989) - et al.
The function of Gp170, the multidrug resistance gene product, in rat liver canalicular membrane vesicles
J Biol Chem
(1989) - et al.
Kinetic analysis of hepatobiliary transport of vincristine in perfused rat liver: possible roles of P-glycoprotein in biliary excretion of vincristine
J Hepatol
(1992) - et al.
Rat liver canalicular membrane vesicles
J Biol Chem
(1983) - et al.
Comparison of bile acid binding to sinusoidal and bile canalicular membranes isolated from rat liver
Biochim Biophys Acta
(1987) - et al.
Characterization of rose bengal binding to sinusoidal and bile canalicular plasma membrane from rat liver
Biochim Biophys Acta
(1989) - et al.
ATP/Mg2+-dependent binding of vincristine to the plasma membrane of multidrug-resistant K562 cells
J Biol Chem
(1988) - et al.
Chromatographic analysis of vinca alkaloids in human neoplastic tissues and host (mouse) tissues after injection in vivo or after incubation in vitro
Anal Biochem
(1983) - et al.
Pharmacokinetic study on the mechanism of tissue distribution of doxorubicin: interorgan and interspecies variation of tissue-to-plasma partition coefficients in rats, rabbits and guinea pigs
J Pharm Sci
(1984)
Mechanism of multidrug resistance and implications for therapy
Jpn J Cancer Res (Gann)
(1988)
Expression of a multidrug-resistance gene in human tumors and tissues
Proc Natl Acad Sci USA
(1987)
Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues
Proc Natl Acad Sci USA
(1987)
Immunohistochemical localization in normal tissues of different epitopes in the multidrug transport protein P 170: evidence for localization in brain capillaries and crossreactivity of one antibody with a muscle protein
J Histochem Cytochem
(1989)
Cited by (44)
Modulation of P-glycoprotein efflux pump: Induction and activation as a therapeutic strategy
2015, Pharmacology and TherapeuticsPolymorphisms in genes involved in vincristine pharmacokinetics or pharmacodynamics are not related to impaired motor performance in children with leukemia
2010, Leukemia ResearchCitation Excerpt :The MDR-1 gene, encoding the efflux pump P-gp, affects the distribution of drugs such as VCR. P-gp has been shown to influence biliary clearance of VCR [14,15,29]. P-gp is located in the blood–nerve barrier and can limit VCR exposure of the nerves [30,31].
Insulin therapy restores impaired function and expression of P-glycoprotein in blood-brain barrier of experimental diabetes
2008, Biochemical PharmacologyCitation Excerpt :Treatment of the rats with insulin for 3 and 5 weeks significantly restored the brain-to-plasma concentration ratio of VCR and reversed the impaired P-GP expression and mdr1a/mdr1b mRNA levels in comparison with the untreated diabetic rats. VCR is a typical substrate of P-GP, and is often used to evaluate the function of P-GP in vivo [26,27]. The brain-to-plasma concentration ratio of a drug is indicative of the degree of a drug's penetration across BBB.
Role of P-glycoprotein in tissue uptake of indinavir in rat
2006, Life Sciences
Copyright © 1995 Published by Elsevier B.V.