Mode of action of benzimidazoles
Abstract
Benzimidazoles represent the only class of truly broad-spectrum anthelmintics, however, they also show activity against fungi and mammalian cells. This raises the question as to why benzimidazoles can selectively kill helminths and yet exhibit little or no mammalian toxicity. In this paper, Ernest Lacey examines this example of selectivity of drug action to the ubiquitous target of these drugs, the structural protein, tubulin.
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Human gnathostomiasis: A review on the biology of the parasite with special reference on the current therapeutic management
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In vivo and in silico investigations on the efficacy of albendazole against Enterocytozoon hepatopenaei (EHP) infecting Penaeus vannamei
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Albendazole – Ivermectin combination decreases inflammation in experimental neurocysticercosis
2023, Experimental ParasitologyNeurocysticercosis (NCC) is a public health issue in endemic regions and is considered the main preventable cause of neurologic disease. It is caused by the presence of Taenia solium cysticercus in the central nervous system. The current treatment is performed with anthelminthic drugs – albendazole (ABZ) or praziquantel – associated with anti-inflammatory and corticosteroids in order to prevent the negative effects of the inflammatory reaction to the parasite's death. Ivermectin (IVM) is an anthelminthic drug that has been shown to present an anti-inflammatory effect. The aim of this study was to was to evaluate the histopathologic aspects of experimental NCC after in vivo treatment with a combination of ABZ-IVM. Balb/c mice were intracranially inoculated with T. crassiceps cysticerci and after 30 days of infection were treated with a single dose of NaCl 0.9% (control group), ABZ monotherapy (40 mg/kg), IVM monotherapy (0.2 mg/kg) or a combination of ABZ-IVM. 24h after the treatment the animals were euthanized and the brain was removed for histopathologic analysis. The IVM monotherapy and ABZ-IVM combination showed more degenerated cysticerci, less inflammatory infiltration, meningitis and hyperemia than the other groups. Therefore, it is possible to recommend the combination of albendazole and ivermectin as alternative chemotherapy for NCC due to its antiparasitic and anti-inflammatory effects, with potential to decrease the negative effects of the inflammatory burst when the parasite is killed within the CNS.
Gallium nitride-polyaniline-polypyrrole hybrid nanocomposites as an efficient electrochemical sensor for mebendazole detection in drugs
2023, Electrochimica ActaThis study investigates the electrochemical sensing behavior of a gallium nitride-polyaniline-polypyrrole (GaN-PANI-PPy) hybrid composite towards mebendazole (MBZ). Followed by synthesis, the MBZ drug was detected by differential pulse voltammetry using GaN-PANI-PPy modified glassy carbon electrode as working electrode which shows linear responses towards the MBZ drug in the concentration range of 3 × 10−7 - 9 × 10−8 M with the sensitivity of 3.02 µA/µM cm−2. The detection limit (DL) and quantification limit (QL) were calculated to be 2.581 × 10−8 M µA−1 and 8.973 × 10−8 M µA−1 respectively with signal-to-noise ratios of 3. By observing the of reproducibility, long-term stability, and anti-interference ability, the prepared GaN-PANI-PPy electrode is considered to be suitable for the electrochemical sensing detection of MBZ in liquid samples such as anti-helthiminic drug milk.
Fenbendazole treatment against Dentostomella translucida in Syrian golden hamsters
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