The active site of cytochrome P-450 nifedipine oxidase: a model-building study

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Abstract

A model of the active site of cytochrome P-450 nifedipine oxidase is built on the basis of sequence homology with cytochrome P-450CAM. Substrates are docked into the binding pocket, and molecular mechanical energy minimization is performed to analyze the forces between the substrates and the enzyme.

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    Dr. Ferenczy's permanent address is Chemical Works of Gedeon Richter Ltd., Budapest, pOB 27, H-1475, Hungary.

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