Intracellular pH regulation in hep G2 cells: Effects of epidermal growth factor, transforming growth factor-α, and insulinlike growth factor-II on exchange activity☆,☆☆
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NHE1 deficiency in liver: Implications for non-alcoholic fatty liver disease
2014, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Indeed, increased NHE activity has been associated with hepatocyte proliferation, regeneration and growth [53]. NHE1 expression and activity are increased in HCC, with NHE1 inhibition limiting HCC tumor growth [54,55]. Inhibition of NHE activity has also been reported to attenuate liver fibrosis [56], indicating a role for augmented Na+/H+ exchange in HSC activation and proliferation [57].
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2013, Seldin and Geibisch's The KidneyControl of Intracellular pH
2012, Seldin and Giebisch's The Kidney: Physiology and PathophysiologyNotch signaling in hepatocellular carcinoma: Guilty in association!
2012, GastroenterologyIntracellular pH regulation by Na<sup>+</sup>/H<sup>+</sup> exchanger-1 (NHE1) is required for growth factor-induced mammary branching morphogenesis
2012, Developmental BiologyCitation Excerpt :Determining how mammary tissue integrates and regulates signals elicited by growth factors is critical to a better understanding of both morphogenesis and cancer. In cell cultures, an inherent downstream event of growth factor signaling is an associated intracellular pH (pHi) alkalization, which has been implicated to induce metabolism and proliferation (Grinstein et al., 1989; Moolenaar et al., 1983; Putney and Barber, 2003; Steffan et al., 2010; Strazzabosco et al., 1995). Yet at the tissue level, the occurrence, regulation, and subsequent importance of pHi alkalization during growth factor-induced morphogenesis has not been investigated.
Activation of Na<sup>+</sup>/H<sup>+</sup> exchanger 1 by neurotensin signaling in pancreatic cancer cell lines
2010, Biochemical and Biophysical Research CommunicationsCitation Excerpt :Stimulation of NHE1 leading to increased cytosolic pH was furthermore shown to be an early event in oncogenic transformation and proved to be essential for the maintenance of the malignant phenotype [23]. Early reports regarding pH-regulation in cancer cells revealed that growth factors like EGF and TGF-α stimulated Na+/H+ exchange and cell proliferation in an amiloride-sensitive manner [24]. In addition, we demonstrated for the first time that NT induced NHE1-dependent intracellular alkalinization mediated by MSK1/2 in pancreatic cancer cells [9].
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This work has been sponsored by grant 94.02908.CTO4 and “Progetto Nazionale Invecchiamento” from Consiglio Nazionale delle Ricerche (Italy) and by “Centro per lo studio dell'invecchiamento,” University of Padova.
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This work has been presented at the AASLD meeting '92 and published as an abstract in HEPATOLOGY 1992; 16: 138A.
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Dr. Zsembery was a recipient of an International Fellowship from the University of Padova.