New metabolites of thiabendazole and the metabolism of thiabendazole by mouse embryo in vivo and in vitro
References (19)
- et al.
Protein measurement with the Folin phenol reagent
Journal of Biological Chemistry
(1951) - et al.
Nephrotoxicity of thiabendazole in mice depleted of glutathione by treatment with dl-buthionine sulphoximine
Food and Chemical Toxicology
(1990) - et al.
Teratogenicity of thiabendazole in ICR mice
Food and Chemical Toxicology
(1984) - et al.
Effects of pretreatment with SKF-525A or sodium phenobarbital on thiabendazole-induced teratogenicity in ICR mice
Food and Chemical Toxicology
(1987) - et al.
Effects of thiabendazole on the kidneys of ICR mice
Food and Chemical Toxicology
(1989) - et al.
Absorption, metabolism, and excretion of thiabendazole in man and laboratory animals
Toxicology and Applied Pharmacology
(1966) - et al.
Irreversible in vivo and in vitro binding of thiabendazole to tissue protein of pregnant mice
Food and Chemical Toxicology
(1986) - et al.
The maternal-foetal distribution of thiabendazole administered in two different vehicles to pregnant mice
Food and Chemical Toxicology
(1984) - et al.
Irreversible in vivo binding of thiabendazole to macromolecules in pregnant mice and its relation to teratogenicity
Food and Chemical Toxicology
(1985)
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Modulation of immune functions, inflammatory response, and cytokine production following long-term oral exposure to three food additives; thiabendazole, monosodium glutamate, and brilliant blue in rats
2021, International ImmunopharmacologyCitation Excerpt :Thus, TBZ can easily remain a pesticide residue in food products [11]. Various reports have shown the TBZ negative impacts on animals and humans, including thyroid disturbances [12], anemia [13], teratogenicity [12], kidney injury [14], hepatic damage [15], and cytogenotoxicity [16]. TBZ has earlier been revealed to boost immune reaction at small doses or in the immunosuppressed host but to be immunosuppressive at relatively high dosages [17,18].
The fungicide thiabendazole causes apoptosis in rat hepatocytes
2016, Toxicology in VitroCitation Excerpt :Parenchymal liver damage caused by thiabendazole has occasionally led to irreversible hepatic failure (FDA, 2003; EMA, 2004). Besides liver toxicity, thiabendazole causes damage to thyroid and developmental processes (Fujitani et al., 1991) and is a potent nephrotoxin, leading to severe kidney damage (Mizutani et al., 1990). The liver is the main site of metabolism of drugs and environmental pollutants, mostly by cytochrome P450 (CYP) isoenzymes, which convert these compounds into more hydrophilic and less toxic compounds that can be easily eliminated from the organism (Brown et al., 2008; Badal and Delgoda, 2014).
Myeloperoxidase-mediated bioactivation of 5-hydroxythiabendazole: A possible mechanism of thiabendazole toxicity
2011, Toxicology in VitroCitation Excerpt :Teratogenicity and carcinogenicity, possibly linked to the changes in gene expression mentioned above, have been associated with TBZ therapy. TBZ is a known teratogen to ICR mice and mouse embryos are capable of metabolizing TBZ to 5OH-TBZ (Fujitani et al., 1991). TBZ has been linked with alterations in cell cycle regulation following spindle disruption (Holden et al., 1980).
Effects of thiabendazole (TBZ) on mitochondrial function in renal cortex of ICR mice
1999, Food and Chemical ToxicologyAcute renal toxicity of thiabendazole (TBZ) in ICR mice
1992, Food and Chemical Toxicology