Original contributionSeizures associated with poisoning and drug overdose
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The effect of antioxidants in acute amitriptyline poisoning
2019, Toxicology ReportsCitation Excerpt :Amitriptyline can cause serious complications, such as compartment syndrome of abdominal viscera, irreversible damage to the central nervous system and lethal ventricular tachycardia. [6] It also has a key role in tissue damage especially the central nervous and cardiovascular systems via free radical-induced oxidative stress [7]. In a series of 110 cases of overdose by amitriptyline for suicide attempts by adult single women admitted to the emergency department of Dicle University Hospital, Turkey (Güloglu C et al).
Approaches for early identification of abuse potential liability
2018, Advanced Issue Resolution in Safety PharmacologyChlorpheniramine produces spinal motor, proprioceptive and nociceptive blockades in rats
2015, European Journal of PharmacologyCitation Excerpt :H1 receptors are found within the CNS. Extreme CNS excitation, such as convulsions, is a manifestation of H1-receptor antagonist neurotoxicity (Olson et al., 1993). We did not evaluate whether local injection of chlorpheniramine produced neurotoxicity.
Acute isoniazid poisoning: Seizure in a patient on anti-tuberculosis treatment
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2014, Encyclopedia of Toxicology: Third EditionFebrile and other occasional seizures
2013, Handbook of Clinical NeurologyCitation Excerpt :Cocaine intoxication and benzodiazepine withdrawal were the most frequent causes followed by psychotropic drug use (Pesola and Avasarala, 2002). Another study reported that drug-induced seizures were associated with cyclic antidepressants in 29%, psychostimulant drugs in 29%, antihistaminics in 14%, theophylline in 5%, and isoniazid in 5% but causative agents have evolved between studies over the past 15 years (Olson et al., 1993; Thundiyil et al., 2007). Here we will focus on medications most used for the comorbidities observed in a pediatric epilepsy practice.
Supported in part by grant no. R49CCR903697 from the National Center for Injury Prevention and Research, Centers for Disease Control, Atlanta, GA.